肛泰3种给药途径对大鼠血清盐酸小檗碱浓度的影响

Influences on Pharmacokinetics of Hydrochloric Berberine in Rats Administrated Gangtai with 3 Routes

目的观察和比较肛泰主要成分之一盐酸小檗碱经腹部皮肤、直肠和口服给药后在大鼠体内的药动学变化。方法通过腹部皮肤和直肠单次给予大鼠肛泰,口服给予等量的盐酸小檗碱溶液,采用HPLC法测定了这3种途径给药后不同时间(0～30h)大鼠血清中小檗碱浓度。结果肛泰贴敷、直肠和口服给药的Tmax分别为1、0.5、0.5h,Cmax分别为127.4、269.4、127.9g/L,AUC0～30h分别为1611.44、1055.61、765.88g/(L·h)。结论本实验为肛泰的临床应用提供了动物体内的药动学参考。

Objective To observe and compare the pharmacokinetics of hydrochloric berberine in rats administrated Gangtai by 3 routes. Method Rats were taken oraUy or administrated Gangtai by abdomen skin or rectal, and their serum concentrations of hydrochloric berberine at different time （0-30 h） were determined with HPLC method. Results The main pharrnacokinetics parameters of hydrochloric berberine by abdomen skin, rectal and oral administration： Cmax was 127.4, 269.4, 127.9 g/L respectively, Tmax was 1, 0.5, 0.5 h respectively, AUC0-30h was 1611.44, 1055.61, 765.88 g/（L· h） respectively. The pharmacokinetics parameters of Gangtai in rats provided academic evidence for clinical application of Gangtai.