摘要
目的研究伴11q23异常的急性粒单细胞和单核细胞白血病患者的临床和细胞遗传学特征。方法用染色体G显带和间期荧光原位杂交技术对30例急性髓系白血病(AML)-M4、M5患者进行染色体检测,患者均接受柔红霉素、阿糖胞苷为主的化疗方案,并对其随访。结果伴11q23异常13例,其中M5 9例(M5 a 1例、M5b 8例)、M4b 5例;异常核型为t(11;19)、t(11;17)、t(9;11)、t(10;11)、t(6;11)、t(11:?)(q23:)、del(11)(q23)。混合细胞白血病(MLL)基因阳性13例,其中M5 8例、M4 5例,其完全缓解(CR)率15.4%,低于MLL阴性者的57.0%;MLL阳性者中位生存期85 d,低于MLL阴性者的130 d。结论11q23异常以AML-M5、M4患者发生率高,MLL阳性者CR率低,平均生存期短。提示MLL基因异常是AML患者预后不佳的标志。
[ Objective] To study the clinical and cytogenetic characteristics of acute myelogenous leukemia （AML- M4/MS） with 11 q23 abnormalities . [ Methods ] 30 cases of AML-M4/M5 were studied by the G-banding techniqne and interphase fluorescence in situ hybridization （I-FISH）. 30 patients were treated with DA （ Daunomycin and Cytarabine）regimen chemotherapy and followed up. [ Results ] 11 q23 abnormalities were found in 13 cases of M4 and MS, 9 cases was M5 （1 M5a, 8 M5b）, 5 cases was M4b. Abnormal karyotype were t （11; 19）, t （11; 17）, t （9; 11）, t （10; 11）, t （6; 11 ）, t （ 11 ; 9. ） （ q23 ;？.）, del （ 11 ） （ q23 ） Mixed lymphocytic lymphoma（MLL） genes were positive in 13 cases, including 8 cases of M5 and 5 cases of M4： The complete remission rate（CR） of MLL was lower （ 15.4% ） than that of MLL negative patients（57% ） ,the median survival of MLL positive patients（ 85 days） was shorter than that of MLL negative patients （ 130 days）. [Conclusion] There is a high incidence of 11q23 abnormalities in AML-M5 / M4, the MLL gene positive patients have lower CR rate and shorter mean survival time . It is indicated that MLL gene abnormality is a sign of poor prognosis in AML patients
出处
《山东医药》
CAS
北大核心
2007年第25期4-6,共3页
Shandong Medical Journal
基金
广东省科技攻关引导项目(06A1212027)
广东省自然科学基金项目(020086)。
