慢病毒载体研究进展

Study on the Development of Lentuiral Vector

慢病毒作为一种特殊的逆转录病毒,与通常使用的逆转录病毒载体和腺病毒载体比较,具有可感染分裂细胞及非分裂细胞、转移基因片段容量较大、目的基因表达时间长、不易诱发宿主免疫反应等优点,已成为当前基因治疗和转基因动物中载体研究的热点。近年来对其基础生物学特性、载体改造及其应用等研究均取得了较大进展。本文就慢病毒载体及应用方面的研究进展作一综述。

As a particular retrovirus, lentivirus possess several advantages such as the capability of infection to dividing cell as well as Unseparated Cell, a large capacity of metastatic gene fragment , a long time of expression of purpose gene and difficult to induce the immune reaction of host and so on when compared with the usually used vectors such as retroviral vector and adenovirus vector, and it becomes to be the hot spot of the vector research in present gene therapy and transgenic animals. It has got certain progress in the research of basic bionomics, vector transforment and application . So it provides an overview of the research in vector construction and applications in the article.