B型钠尿肽在充血性心力衰竭诊断中的价值

Application of B-type natriuretic peptide in congestive heart failure

目的研究B型钠尿肽(BNP)在充血性心力衰竭患者的诊断、病情评估、疗效评价方面的临床价值。方法随机选择住院CHF患者105例,非CHF患者30例,采用美国博适公司生产的Triage快速诊断测定仪进行床边抽血查其血浆BNP浓度,并行心脏彩超检查。结果CHF组总体血浆BNP水平显著高于对照组;BNP浓度增高程度与CHF的严重程度成正相关,与左室射血分数(LVEF)呈负相关。结论BNP的检测有利于CHF患者的早期诊断及病情评估。

Objective To investigate the value of B-type natriuretic peptide （BNP）in the diagnosis,illness evaluation and effect of congestive heart failure （CHF）.Methods The serum BNP concentration of 105 CHF patients and 30 controls were measured rapidly by Triage BNP, and left Ventricular ejection fraction （LVEF） were detected by color Doppler.Results The serum BNP concentration in CHF group was much higher than that in the controls （P〈0.01）,which was positively correlated with NYHA class,and negatively with LVEF.The levels of LVEF and BNP were consistent with those by color Doppler.With the improving of heart function , the level of BNP declined obviously （ P〈0.01）.Conclusion BNP is a useful marker for diagnosis,illness evaluation and therapeutic effect of CHF .