胃粘液癌的肿瘤增殖与 DH_7 识别抗原的表达

Tumour Hyperplasia of Gastric Mucoid Carcinoma and Expression of the Antigen Recognized by Monoclonal Antibody DH 7

应用免疫组化ＡＢＣ法，分析单克隆抗体ＤＨ７识别抗原在１９例胃粘液癌中的表达。结果显示有腺样结构的粘液腺癌阳性率为１００％（９／９），无腺样结构的粘液细胞癌（即印戒细胞癌）阳性率仅为２０％（２／１０），其中２例阳性均属粘液细胞癌的前期——单核细胞样癌细胞形式，而另８例所见的后期印戒样癌细胞均为阴性。提示，粘液癌的肿瘤增殖发生于腺样结构的癌组织和单核细胞样癌组织中，而非发生于散在的印戒样癌细胞中，后者乃是肿瘤增殖后期的终末期癌细胞形式，从而验证了粘液细胞癌从前期单核样癌细胞到后期印戒样癌细胞的这一形态演化过程。

The thesis is intended to analyse the expression of the antigen recognized by monoclonal antibody DH 7 in 19 cases of gastric mucoid carcinomas by means of immunohistochemistry (ABC method). The results showed that the positive rate in mucinous adenocarcinoma with adeneid structure was 100% (9/9), while in signet ring cell carcinomas, the rate was only 20% (2/10). Among them, the 2 positive cases belonged to monocytoid cells, which were on the early stage of mucoid carcinomas. The other 8 cases belonging to late stage similar to finger rings in appearance were all negative. It seems that the multiplication of mucoid carcinoma exists in adenoid structure tumour tissues and monocytiod cells, but not in the signet ring cell that is the form of tumor cell in the end period of hyperplasia. Therefore, it confirms the author in belief that the course of morphologic formation of gastric mucoid carcinoma is from monocytoid cell to late signet ring cell.