帕罗西汀与阿米替林治疗抑郁症对照研究

A controlled study on the treatment of depression with paroxetine and amitriptyline

目的:探索帕罗西汀与阿米替林治疗抑郁症的疗效与安全性。方法:选定58例符合CCMD-3诊断标准的抑郁症患者随机分为两组,分别给予帕罗西汀与阿米替林治疗8周,用汉密尔顿抑郁量表(HAMD)评定临床疗效,用副反应量表(TESS)评定不良反应。结果:两组治疗抑郁症的疗效基本近似,帕罗西汀较阿米替林起效快,不良反应轻。结论:帕罗西汀治疗抑郁症疗效好,不良反应轻。

Objective：To explore the efficacy and side effect of paroxetine and amitriptyline. Methods：58 patients who met CCMD - 3 criterion for depression episode were randomly assigned to paroxetine group （ n = 30 ） and amitriptyline group （ n = 28 ） for the treatment of 8 weeks. The clinical efficacy was evaluated by HAMD. The side effects were evaluated by TESS. Results. There was no significant difference of the efficacy between two groups. Paroxetine showed rapider efficacy and less side effects than amitriptyline. Conclusions： Paroxetine showed sure efficacy and less side effects.