肝癌高发区不同水体对健康人微核率的影响

The Effect of Various Drinking Water on Micronucleus Rate of Human Beings in High Risk Population of PHC

应用微核检测技术，研究不同类型饮用水诱发健康人外周血淋巴细胞的微核效应，结果表明：①不同饮用水的细胞毒作用依次为宅沟水＞泯沟水＞自来水＞重蒸水，其微核诱变效应为泯沟水＞自来水＞重蒸水。②不同饮用水诱发的微核率与饮用相应类型水的居民的肝癌发病率呈平行关系。进一步证实了肝癌高发区饮用水与原发性肝癌的发生密切相关。提示饮用深井水、改进饮水质量是一项行之有效的干预性措施；如能长期坚持，对预防肝癌有着积极的意义。

Using micronucleus test, we studied micronucleus that was effect of human peripheral lymphocytes induced by the various type of drinking water. The results showed: The cytotoxicity of drinking water was in following order:pool water>irrigation canal water>running water>double evaporating water. The micronucleus rate intraduced by various drinking water correlated with the incidence of PHC of patients who drink the corresponding water. These deta comfirmed the deep relationship between drinking water and PHC incidence inhigh risk population of PHC. lt suggested that drinking deep well water, improving the quality of drinking water are the more effect management. lf it instant for a long period, it will get a more effective.