洛沙平与利培酮治疗精神分裂症的临床对照研究

A comparative study of loxapine and risperidone in the treatment of schizophrenic patients

目的:研究洛沙平与利培酮治疗精神分裂症的临床疗效与安全性。方法:80例精神分裂症患者随机分成两组,分别给予洛沙平与利培酮8周,应用PANSS量表和TESS量表分别评价临床疗效和不良反应。结果:两组之间疗效无显著性差异,洛沙平起效快,其常见不良反应为锥体外系反应(EPS)。结论:洛沙平是一种安全、有效、起效快的抗精神病药物。

Objective：To study the efficacy of loxapine and risperidone in the treatment of schizophrenia. Methods：A total of 80 patients were randomly assigned to receiving loxapine or risperidone for 8 weeks. PANSS and TESS were used to measure efficacy and side effects. Results： There was no significant difference in curative effect between two groups （p 〉 0.05 ）. The main side effect of loxapine was extrapyramidal symptom. Conclusions： Loxapine is an effective and safe antipsychotic agent.