Survivin和C-myc在肝门部胆管癌组织中的表达及其相关性研究

Expression and correlation of Survivin and C-myc in hilar cholangiocarcinoma

目的:探讨Survivin和C-myc在肝门部胆管癌中的表达、临床意义及相互关系。方法:用免疫组织化学SP法检测45例肝门部胆管癌及20例非癌胆管组织中Survivin和C-myc的表达。结果:45例肝门部胆管癌组织中Survivin和C-myc的表达率分别为68.9%(31/45)和62.2%(28/45),非癌胆管组织中Survivin和C-myc的表达率分别为0和15%(3/20),差异有统计学意义(P<0.05)。肝门部胆管癌组织中Survivin的表达与淋巴结转移有关(P<0.05),C-myc的表达与肿瘤分化程度和淋巴结转移有关(P<0.05),它们的表达与患者的性别、年龄,肿瘤大小及Bismuth分型无关(P>0.05)。Survivin、C-myc的表达呈正相关关系(P<0.05)。结论:Survivin、C-myc在肝门部胆管癌中的表达呈正相关关系,共同在肝门部胆管癌的发生、发展、转移中起一定作用,Survivin有望成为肝门部胆管癌治疗的新靶点。

Objective： To investigate the expression of Survivin and C-myc with the clinical significance of hilar cholangiocarcinoma and the correlation between the expressions of Survivin and C-myc. Methods： The expressions of Survivin and C-myc in 45 cases of hilar cholangiocarcinoma and in 20 cases of non-carcinoma bile duct tissues were examined by immunohistochemistry. Re. suits： In 45 cases of hilar cholangiocarcinoma, the positive rates of Survivin and C-myc were 68.9% （31/45）and 62.2% （28/45）, the positive rates of Survivin and C-myc in 20 cases of non-carcinoma bile duct tissues were 0 and 15% （3/20）respectively, the difference was significant （P〈0.05）. The expression of Survivin in hilar cholangiocarcinoma was related with lymph node metastasis （P〈0.05）, the expression of C-myc was related with differentiated degree and lymph node metastasis（P〈0.05）. The expressions of Survivin and C-myc had no association with gender（P〉0.05）, age（P〉0.05） and tumor size（P〉0.05）. The correlation between the expressions of Survivin and C-myc was significant （P〈0.05）. Conclusions： The expression of Survivin was significantly related with expression of C-myc in hilar cholangiocarcinoma.