期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

环氧化酶-2与肝损伤 被引量：11

下载PDF
导出
摘要 肝损伤是指各种致病因素(物理、化学和生物性因素)作用于肝组织而引起的肝细胞的变性、坏死及肝功能的改变,多种炎性介质及细胞因子参与了肝损伤的过程。环氧化酶-2(COX-2)为一种诱导酶,当细胞受到炎症等刺激时可高表达,是炎症介导的细胞毒性重要的决定因素之一。在各种原因所导致的肝损伤中,COX-2表达增多的现象提示COX-2在肝损伤发生发展中具有重要作用,COX-2作为肝损伤的治疗靶点将成为今后研究的热点。
作者 吕月涛 刘江伟 冯德元 张永久
机构地区 石河子大学医学院 兰州军区乌鲁木齐总医院普外科
出处 《中国现代普通外科进展》 CAS 2007年第4期341-343,共3页 Chinese Journal of Current Advances in General Surgery
基金 兰州军区医药卫生科研基金资助项目(LXH-2005019)
关键词 环氧化酶-2 肝损伤
分类号 R575.3 [医药卫生—消化系统]
  • 相关文献

参考文献13

  • 1Nanji AA．Role of Kupffer cells in alcoholic hepatitis[J]．Alcohol,2002，27(1)：13-15．
  • 2刘江,施柏年,何建方,戴利成.环氧化酶2在肝衰竭模型肝损伤中的表达[J].第二军医大学学报,2006,27(4):444-446. 被引量：3
  • 3Suh GY，Jin Y，Yi AK，et al．CCAAT／enhancer-binding protein mediates carbon monoxide-induced suppression of cyclooxygenase-2[J]．Am J Respir Cell Mol Biol 2006，35(2)：220-226．
  • 4Yokoyama Y，Xu H，Kresge N，et al．Role of thromboxane A2 in early BDL-induced portal hypertension[J]．Am J Physiol Gastrointest Liver Physiol,2003,284(3)：453-460．
  • 5Ito Y．Katagiri H．Ishii K．et al．Elfeels of selective eyelooxygenase inhibitors on ischemia／reperfusion-induced hepatic microcirculatory dysfunction in mice[J]．Eur surg Res，2003,35(5)：408-416．
  • 6Ganey PE，Barton YW，Kinser S，et al．Involvement of cyclooxygenase-2 in the potentiation of allyl alcohol-induced liver injury by bacterial lipopolysaceharide[J]．Toxicol Appl Pharmacol,2001，174(2)：113-121．
  • 7易辉,王新,苗继延,杜静平,潘阳林,刘娜,张宇梅,樊代明.选择性环氧合酶-2抑制剂对大鼠酒精性肝损伤的保护作用[J].中华肝脏病杂志,2003,11(11):663-666. 被引量：12
  • 8Ahmad N，Chen LC，Gordon MA，et al．Regulation of cyclooxygenase-2 by nitric oxide in activated hepatic maerophages during acute endotoxemia[J]．J Leukoc Biol,2002，71(6)：1005-1011．
  • 9Kim SH，Chu HJ，Kang DH，et al．NF-kappa B binding activity and cyclooxygenase-2 expression in persistent CC1(4)-treated rat liver injury[J]．J Korean Med Sci，2002，17(2)：193-200．
  • 10Ozturk H，Gezici A，Ozturk H.The effect of celecoxib，a selective COX-2 inhibitor,on liver ischemia／reperfusion-induced oxidative stress in rats[J]．Hepatol Res，2006，34(2)：76-83．

二级参考文献16

  • 1Ganey PE, Barton YW, Kinser S, et al. Involvement of cyclooxygenase-2 in the potentiation of allyl alcohol-induced liver injury by bacterial lipopolysaccharide. Toxicol Appl Pharmacol, 2001, 174:113-121.
  • 2Vogel C, Boerboom AM, Baechle C, et al. Regulation of prostaglandin endoperoxide H synthase-2 induction by dioxin in rat hepatocytes: possible c-Src-mediated pathway. Carcinogenesis, 2000,21: 2267-2274.
  • 3Denda A, Kitayama W, Murata A, et al. Increased expression of cyclooxygenase-2 protein during rat hepatocarcinogenesis caused by a choline-deficient, L-amino acid-defined diet and chemopreventive efficacy of a specific inhibitor, nimesulide.Carcinogenesis, 2002, 23: 245-256.
  • 4Nanji AA, Jokelainen K, Tipoe GL, et al. Dietary saturated fatty acids reverse inflammatory and fibrotic changes in rat liver despite continued ethanol administration. J Pharmacol Exp Ther, 2001,299: 638-644.
  • 5Ritter CA, Sperker B, Grube M, et al. Overexpression of glutathione S-transferase A1-1 in ECV 304 cells protects against busulfan mediated G2-arrest and induces tissue factor expression. Br J Pharmacol,2002, 137: 1100-1106.
  • 6Henrion-Caude A, Flamant C, Roussey M, et al. Liver disease in pediatric patients with cystic fibrosis is associated with glutathione S-transferase P1 polymorphism. Hepatology, 2002, 36(4 Pt 1):913-917.
  • 7Kanbagli O, Balkan J, Aykac-Toker G, et al. Hepatic mitochondrial prooxidant and antioxidant status in ethanol-induced liver injury in rats. Biol Pharm Bull, 2002, 25: 1482-1484.
  • 8Williams CS,DuBois RN.Prostaglandin endoperoxide synthase:Why two isoforms[J]? Am J Physiol,1996,270(3 Pt 1):G393-G400.
  • 9Alaaeddine N,Di Battista JA,Pelletier JP,et al.Inhibition of tumor necrosis factor alpha-induced prostaglandin E2 produc tion by the antiinflammatory cytokines interleukin-4,interleukin-10,and interleukin-13 in osteoarthritic synovial fibroblasts:distinct targeting in the signaling pathways[J].Arthritis Rheum,1999,42:710-718.
  • 10Dieter P,Hempel U,Kamionka S,et al.Prostaglandin E2 affects differently the release of inflammatory mediators from resident macrophages by LPS and muramyl tripeptides[J].Mediators Inflamm,1999,65:295-303.

共引文献13

同被引文献157

引证文献11

二级引证文献78

中国现代普通外科进展
2007年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部