彩色多普勒超声对门静脉内应用PVA复制肝内型门脉高压症犬的血流动力学观察

Colour Doppler Ultrasound Investigation on Hemodynamics in Intrahepatic Portal Hypertension Produced by Intraportal PVA Injections in Dog

选杂交犬８只，门静脉内反复注射聚乙烯醇（ＰＶＡ）复制门脉高压症动物模型。６只形成肝内型门脉高压症动脉模型，２只死于术后感染。用药前后，应用彩色多普勒超声技术观察全部实验动物肝脏血流动力学指标，结果显示门静脉、脾静脉血流量有不同程度增加（Ｐ值＜０．０１），３只家犬肠系膜上静脉血流量略有增加（Ｐ值＞０．０５）。

Intrahepatic portal hypertension was produced by intraportal polyvinyl alcohol (PVA) injections in 6 fractions of 8 mongrel dogs, among then two died from postoperative infection. The hemodynamic indexes of portal circulation in all experinental animals were investigated by Doppler ultrasound before and after usins the drags. The results showed that blood flow in portal and spenic vein increased at various degree (P<0.01), however, in superior mesenteric vein it was slightly increased is 3 dogs (P>0.05). These provided important hemodynamic parameters for the early diagnosis of portal hypertension.