摘要
目的：颅脑肿瘤注入Ｇｄ－ＤＴＰＡ（磁显葡胺）以区别瘤体与水肿，鉴别肿瘤良、恶性及囊壁，显示脑转移瘤和子瘤灶，达到临床诊断目的；资料和方法：７２例颅脑肿瘤，其中脑内肿瘤４８例，脑外肿瘤２４例。均用ＡＳＭ－０１５Ｐ永磁型ＭＲＩ扫描机，采用头线圈，ＳＥ序列：Ｔ１加权像ＴＲ＝５００ｍｓ，ＴＥ＝３０ｍｓ，Ｔ２加权像ＴＲ＝２０００－３０００ｍｓ，ＴＥ＝１００－１２０ｍｓ，，层厚５－１０ｍｍ，方位行横、冠、矢状位，增强扫描为：静脉缓慢注入Ｇｄ－ＤＴＰＡ（磁显葡胺）按０１－０２ｍｌ／ｋｇ体重，注药后５、１０、２５、３５ｍｉｎ作相应方位Ｔ１加权像扫描；结果：１脑内肿瘤４８例，胶质瘤３３例，明显及部分强化２５例，不强化８例，脑转移１５例均强化共３９个瘤灶（其中新发现８个）；（２）脑外肿瘤２４例，脑膜瘤１４例，垂体瘤６例，听神经瘤３例上述均强化，硬膜外表皮样囊肿１例不强化；结论：颅脑肿瘤通过静脉注入Ｇｄ－ＤＴＰＡ（磁显葡胺）可以明确瘤灶与水肿及发现Ｔ２加权像上被水肿掩盖的子灶，达到临床诊断目的。
PURPOSE: By means of venous injection of Gd-DTPA, benign and malignant cranioverebral tumors as well as their walls can be differenciated; and the cerebral metastases of tumors and seeding focus can be showed in order to obtain the clinical diagnoses;MATERIAL ANP METHDD: 72 cases of craniocerebral tumors were diagnosed including intracerebral tumors (48 cases),extracerebral tumors(24 cases),which have been identified by means of operation, pathology of clinical follow-up. Permenant Magnetic Model MRI scanner (0 15T ASM-O15P)was used with head coil, SE Senes:T 1 weighted image TR=500ms,TE=30ms, T 2 weighted image TR=2000-3000ms TE=100-120ms, slice thickness 5-10mm, Transverse, Coronal and Sagittal location. Gd-DTPA(0 1-0 2ml/per kg body weight)was slowly injccted intravenously to intensify MRI scanning. The relative position scaning were down 5,10, 25,35min post-injection; RESULTS: (1)Of the 48 cases of intacerebral tumor ,33 cases were gliomas, the apparent and partial intensified were 25 cases, no intensefied 8 cases, Cerebral metastasis of tumors intensified completely 15 cases. There are 39 tumors all together(among them, 8 cases were newly fourded)(2)Of the 24 cases Extracerebral tumors:including 14 cases of meningioma, 6 cases of pituitary tumor, 3 cases of Acoustic neuroma. All of them were intensified. Only the one case of epidural epidermoid cyst was not intensified;CONCLUSION: Throngh injection intavenously with Gd-DTPA, the focus, oedema and seeding focus, which was covered by oedema in T 2weighted image, could be discovered by MRI scanning, So the diagnosis can be made.
