奥美拉唑治疗轻中型溃疡性结肠炎临床研究

Clinical Investigation about Omeprazole in Treating Miffs and Moderately Ulcerative Colitis

目的:研究奥芙拉唑治疗轻中型溃疡性结肠炎的临床疗效。方法:治疗组口服奥美拉唑,疗程为2周.观察其疗效及不良反应,并与柳氮磺胺吡啶组相比较。结果:奥芙拉唑组总有效率为93%,治疗过程中无不良反应发生,柳氮磺胺吡啶组总有效率为71%,两组疗效比较差异有显著性。结论:奥美拉唑治疗轻中型溃疡性结肠炎患者疗效确切,无不良反应,适用于柳氮磺胺吡啶耐受性差的轻中型溃疡性结肠炎患者。

Objective To investigate the clinical efficacy of omeprazole for treating mitis and moderately ulcerative colitis. Methods Omeprazole was used to treat patients with mitis or moderately ulcerative colitis. After two weeks, its therapeutic effects and adverse effects were observed. Meanwhile,patients in control group were treated with salazosulfapyridine. Results Total effective rate for the group used omeprazole was 93% and no adverse effects were observed. Control group has a 71% total effective rate, significant lower than omeprazole group. Conclusion Omeprazole have definite effects for patients with mitis or moderately ulcerative colitis and it seldem causes adverse effects. Omeprazole is an effective hterapy for ulcerative colitis patients especially who cannot tolerate salazosulfapyridine.