复方甘草酸单铵注射液联合还原型谷胱甘肽治疗抗结核药肝损害疗效观察

Compound Ammonium Glycyrrhetate Injection plus Reduced Glutathione for Hepatic Lesion Induced by Anti-tubercular Drugs: Observation of Curative Efficacy

目的：观察复方甘草酸单铵注射液联合还原型谷胱甘肽治疗抗结核药肝损害的临床疗效。方法：158例抗结核药肝损害患者按出现肝损害先后分组，前73例为对照组，给予常规保肝治疗，后85例为治疗组，给予复方甘草酸单铵注射液和还原型谷胱甘肽治疗，疗程均为2-4wk，保肝同时继续抗结核药治疗。结果：治疗4wk，治疗组与对照组治愈率分别为70．6％、45，2％（P〈0．01），总有效率分别为96．5％、76．7％（P〈0．01），治疗组在症状缓解程度和恢复肝功能方面均明显优于对照组（P〈0．01）。结论：复方甘草酸单铵注射液联合还原型谷胱甘肽治疗抗结核药肝损害疗效确切。

OBJECTIVE- To observe the clinical therapeutic efficacy of compound ammonium glycyrrhetate injection plus reductive glutathione in the treatment of hepatic lesion induced by anti - tuberculous drugs.METHODS：A total of 158 patients with hepatic lesion induced by anti -tuberculous drugs were divided into two groups according to the order of onset time of hepatic lesion： the first 73 cases（control group） were assigned to receive the common hepatoprotective therapy, while the following 85 cases（trial group） to receive compound ammonium glycyrrhetate injection plus reductive glutathione for 2-4wk in addition to the hepatoprotective therapy and the continuing use of antituberculosis drugs.RESULTS：After 4- week treatment, the cure rates in the trial group and the control group were 70.6% and 45.2% （P〈0.01）,respectively,and the total effective rates were 96.5% and 76.7% （P 〈 0.01）respectively.As compared to the control group, the treatment group was significantly superior with regard to the symptomatic relief degree and liver function recovery（P〈0.01）.CONCLUSION ：The combination of compound ammonium glycyrrhetate injection and reductive glutathione has affirmed efficacy in the treatment of hepatic lesion induced by anti - tuberculous drugs.