大鼠异位心脏移植术的改进

IMPROVED RAT HETEROTOPIC CARDIAC TRANSPLANTATION

目的：研究心脏移植排异反应和筛选新的免疫抑制剂。方法：在陈忠华术式的基础上，将血管吻合口改在肾静脉和腰静脉之间，结扎但不切断下腔静脉一背支，手术时将大部分肠袢拉到腹腔外使血管暴露清楚，肉眼下直接进行吻合。结果：手术成功率达９１％（５１／５６），且不需手术显微镜。结论：本术式操作简单易行，易于推广。

Objective:To study cardiac transplantation rejective reaction and screen new immunosuppresive agents.Methods:The method reported till now has disadvantage of easily bleeding,requiring operating microscope and complicated micro surgical procedures.On the basis of Chens method,anastomosis was done between kidney vessels and lumbar veins;a back branch of vena cava was ligated but not cut off and part of intestine was pulled out of abdominal wall to show aorta and vena cava clearly.Results:Successful rate of heterotopic cardiac transplantation is 91%(51/56).Conclusion:This method has advantage of simpleness,less bleeding and requiring no operating microscope,so it is easily be to spreaded.