血管内皮生长因子与冠心病的关系分析

Correlative study of vascular endothelial growth factor and coronary heart disease

目的通过测定不同冠状动脉粥样硬化性心脏病(CHD)患者血清中血管内皮生长因子(VEGF)的水平,分析在不同情况下VEGF水平变化,并分析其与冠心病的关系。方法选取诊断为CHD,并完成冠状动脉造影术患者142例,其中男性67例,女性75例,应用双抗夹心ELISA法检测患者血清VEGF水平。结果不稳定型心绞痛(UAP)患者VEGF水平明显高于稳定型心绞痛(SAP)患者[(663.58±109.21)pg/ml和(537.47±29.37)pg/ml](P<0.05);SAP患者与陈旧性心肌梗死(OMI)患者相比差异无统计学意义;SAP患者、UAP患者、OMI患者较冠状动脉造影正常者VEGF水平明显增高[(537.47±29.37)pg/ml、(663.58±109.21)pg/ml、(544.53±30.60)pg/ml和(463.58±60.12)pg/ml],(P<0.05),而急性心肌梗死(AMI)患者发病第1天VEGF水平较SAP者无明显升高,但第2、3天VEGF水平较SAP者明显升高。结论不同程度CHD患者中VEGF水平差异有统计学意义,VEGF与心肌缺血,以及缺血的时间密切相关,可能对于患者病情评价存在较大价值。

Objective To investigate the predictive values of VEGF for coronary heart disease and the relationship between VEGF and CHD. Methods All subjects（ 142 patients） were enrolled from inpatients who underwent coronary angiography. VEGF were determined by enzyme-linked immunosorbent assay （ELISA）. Results The serum VEGF levels of UAP patients were higher than that of SAP patients[ （663.58± 109.21 ）pg/ml and（537.47± 29,37）pg/ml] ,P〈0.05. There is not significant difference between the serum VEGF levels of SAP patients and that of OMI patients [ （537.47±29.37）pg/ml, （663.58± 109.21 ）pg/ml, （ 544.53±30.60 ）pg/ml and （ 463.58±60.12 ）pg/ml ]. The serum VEGF levels in all the three groups patients were higher than that in normal controls.And the serum VEGF levels of AMI patients in the first day are not higher than that of SAP patients, but much higher in the next two days. Conclusion The results suggest that the serum VEGF level might reflect the different levels of myocardial ischemia among the CHD patients.