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色素上皮衍生因子的抗肿瘤潜能

Pluripotent anti- tumor potentials of pigment epithelial- derived factor
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摘要 色素上皮衍生因子（PEDF）是一种内源性的非抑制性丝氨酸蛋白酶抑制剂,具有神经营养、神经保护、抗血管生成、抗血管渗漏和促进凋亡等生物学活性。研究表明,PEDF可以直接或间接地抑制肿瘤,从而有望成为潜在的抗肿瘤药物。 Pigment epithelial-derived factor （PEDF） is an endogenous non inhibitory serine proteinase inhibitor. PEDF has complex activities such as neurotrophy, neuroprotection, anti-angiogenesis, anti-vasopermeability and promotion of apoptosis. PEDF in recent studies shows promise as a potential anti-tumour agent, causing both direct and indirect tumour suppression.
作者 余明华（综述） 韩建群（综述） 修瑞娟（审校）
机构地区 中国医学科学院中国协和医科大学微循环研究所
出处 《国际肿瘤学杂志》 CAS 2007年第8期569-573,共5页 Journal of International Oncology
关键词 神经生长因子 受体 神经生长因子 血管生成抑制剂 肿瘤 Nerve growth factor Receptor, nerve growth factor Angiogenesis inhibitors Neoplasms
分类号 R730.23 [医药卫生—肿瘤]
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参考文献30

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国际肿瘤学杂志
2007年 第8期

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