三苯氧胺对子宫内膜癌的潜在致癌作用机制

Mechanisms of potential oncogenic effect of tamoxifen on endometrial cancer

三苯氧胺是一种具有抗雌激素作用的非甾体类化合物,已成为各期乳腺癌患者的一线内分泌治疗药物。但最新的临床研究表明,使用三苯氧胺作为辅助治疗的乳腺癌患者并发子宫内膜癌的危险性增加。通常认为,三苯氧胺在乳腺组织中具有抗雌激素作用,但是在子宫内膜细胞中却表现出类雌激素作用。越来越多的临床试验正聚焦于三苯氧胺与子宫内膜癌的关系,三苯氧胺对子宫内膜的潜在致癌作用机制也成为当前研究的一项热点。

TAM is a synthetic non-steroid compound with strong antiestrogen properties. It has been the endocrine treatment choice in the first-line therapy for all stages of breast cancer. But recent clinical studies indicate an increasing risk of subsequent endometrial carcinoma in breast cancer women who take TAM as an adjuvant therapy. It is thought generally that while acting as an estrogen antagonist in the breast tissue, tamoxifen has estrogenic effects on the endometrium cells. More and more clinical trials are focusing on the relationship between tamoxifen use and the risk of endometrial cancer. The mechanism of the potential oncogenic effect of tamoxifen on the endometrial cancer has also been the recent focus research.