氟西汀与马来酸曲美布汀联合治疗功能性消化不良的临床观察

Clinical Observation on Treating Functional Dyspepsia by the Joint Use of Fluoxetine and Maleic Acid Trimebutin

目的:探讨氟西汀与马来酸曲美布汀联合治疗功能性消化不良(FD)的疗效。方法:将门诊160例FD患者随机分成甲、乙两组,甲组80例予以马来酸曲美布汀治疗,乙组80例予以马来酸曲美汀与氟西汀联合治疗,治疗时间均为8周,以自制FD症状评定量表评定疗效。结果:甲、乙两组有效率分别为62.5%(50例),91.25%(73例),疗效差异有显著性(P<0.01)。结论:氟西汀与马来酸曲美布汀联合使用可显著提高治疗FD的疗效,值得推广。

Objective： To explore the effectiveness of combining Trimebutine Maleate and Fluoxetine to cure Functional Dyspepsia （FD） . Methods： Dividing 160 people who have FD into two groups in random ,80 people in group A are cured by Trimebutine Maleate , and the others in group B are cured by both Trimebutine Maleate and Fluoxetine , the curing time are about 8 weeks. The effectiveness of it are evaluated by a self-made FD syndrome evaluation form. Result. The effectiveness of group A and B are 62. 5 % and 91.25 % respectively , there are huge differences between the curing effectiveness （P〈0. 01 ） . Conclusion. Combining Trimebutine Maleate and Fluoxetine to cure Functional Dyspepsia （FD） increase the effectiveness of curing FD dramatically , and it should be promoted.