星状神经节阻滞对特发性面神经麻痹患者红细胞免疫功能的影响

The influence of stellate ganglion block on erythrocytes immunity in patient of Bell′s palsy

目的观察星状神经节阻滞(SGB)对特发性面神经麻痹患者红细胞免疫功能的影响。方法将起病到确诊7d内的患者44例随机均分为两组,星状神经节阻滞组(A组),常规治疗组(B组);另选择22名健康人为正常对照组(C组)。观察A、B两组患者不同时点的丙二醛(MDA)、超氧化物歧化酶(SOD)、红细胞C3b受体花环率(RBC-C3bRR)、红细胞免疫复合物花环率(RBC-ICR)以及面部表情肌数量级量化评分;C组单次取血测定以上指标设为正常对照值。结果(1)治疗前A、B两组间MDA、RBC-ICR差异无统计学意义,但两组均高于C组(P<0.05)。两组治疗后MDA含量、RBC-ICR均明显低于治疗前(P<0.05),A组又明显低于B组(P<0.05)。(2)治疗前A、B组间RBC-C3bRR、SOD差异无统计学意义,但A、B组均低于C组(P<0.05),治疗后两组RBC-C3bRR、SOD均明显高于治疗前(P<0.05),A组又明显高于B组。(3)治疗后两组面部表情肌数量级量化评分均较治疗前明显提高(P<0.05),A组分值改善情况优于B组(P<0.05)。结论特发性面神经麻痹患者红细胞免疫功能低于正常人,星状神经节阻滞能提高特发性面神经麻痹患者红细胞免疫黏附功能,缩短痊愈时间。

Objective To study the effects of stellate ganglion block （SGB） on erythrocytes immunity in patients with Bell＇s palsy. Methods Forty-four patients with Bell＇s palsy were randomly divided into SGB group （group A, n： 22） and traditional therapy group （group B, n = 22）. Another 22 health people were chosen as control group （group C）. MDA, SOD, RBC-Cab RR, RBC-ICR of groups A and B were measured before and on the lst,Sth and 10th day after therapy. Results （1） MDA and RBC-ICR of group A and B were similar before treatment, which were higher than those of group C and than those after treatment. （2） SOD and RBC-Cab RR of group A and B were similar before treatment,which were lower than those of group C and lower than those after treatment,but those in group A was higher than those of group C and lower those after treatment. （3）The facial expression of both group A and B were improved markedly after treatment, which was better in group A than that in group B. Conclusion The immunity function of erythrocytes in patients with Bell＇s palsy is poorer than that in healthy people. SGB could improve the immunity function of erythrocytes in those patients.