CD82/KAI1基因蛋白在62例胃癌中的表达

An Analysis of CD82/KAI1 Expression in 62 Cases with Gastric Cancer

[目的]探讨胃癌组织中抑癌基因CD82/KAI1蛋白的表达与胃癌临床生物学行为及预后的关系。[方法]采用免疫组织化学方法检测62例胃癌原发灶、阴性组织切缘中CD82/KAI1基因蛋白产物的表达。[结果]胃癌组织中KAI1蛋白阳性表达率为72.5%,显著低于阴性组织切缘的95.2%(P<0.01)。KAI1蛋白在浸润深度的T3+T4组(65.1%)较T1+T2组(89.5%);低分化组(20.5%)较高、中分化组(88.9%);淋巴结转移组(59.1%)较无淋巴结转移组(94.4%);TNM分期中的Ⅲ～Ⅳ期组(63.4%)较Ⅰ～Ⅱ期组表达(90.5%)均降低(P<0.05)。胃癌组织中的KAI1蛋白表达与患者性别、年龄、肿瘤大小、Lauren分型无关,胃癌患者生存期5年以下组的胃癌组织中KAI1蛋白的表达水平明显低于生存期5年以上组(P<0.05)。[结论]胃癌组织中KAI1基因蛋白表达降低与胃癌的侵袭、转移及临床病理进展有关。

[Purpose] To explore the relationship of CD82/KAI1 expression with clinical biological behavior and prognosis of gastric cancer. [Methodl The specimens from 62 cases with gastric caner and their CD82/KAI1 expression both in primary gastric cancer focus and in negative tissue margin were detected by S-P immunohistochemical technique. [Results] The positive expression rate of KAI1 was 72.5% in gastric cancer tissue, which was significantly lower than that in negative tissue margin （95.2%, P〈0.01）. The KAI1 expression was lower in group of T3＋T4 （TNM staging system） than that in group of T1＋T2 （65.1% vs. 89.5%）; in poor differentiation group than that in moderate or well differentiation group（20.5% vs. 88.9%）; in lymph node metastasis group than that in without lymph node metastasis group（59.1% vs. 94.4%）; Ⅲ-Ⅳ group（TNM stage） than that Ⅰ -Ⅱ group（63.4% vs. 90.5%） （P〈0.05）. It also showed that the KAI1 expression in gastric cancer tissue had no relationship with sex, age, tumor size or Lauren type. The KAI1 expression in 〈 5-year survival group was lower than that in 〉5-year survival group（P〈0.05）. [Conclusion] The decreasing expression of KAI1 may be an important factor influencing prognosis, invasion, metastasis in patients with gastric cancer.