玉米须多糖降低实验动物体重的作用机制研究

A study on mechanisms of stigma maydis polysaccharide on weight loss in experimental animals

目的研究玉米须多糖(SMPS)减轻实验动物体重的作用机制。方法观察SMPS灌胃后,小鼠和大鼠胃排空、肠蠕动、胆汁分泌量、胆囊重量、体重、摄食量、血浆胆囊收缩素(CCK)含量的变化。结果SMPS能够增加小鼠甲基橙胃残留率、小肠炭末推进百分率,缩短首次排黑便时间,增加排便数量,减轻胆囊重量;同时发现,SMPS能够抑制大鼠食欲,减轻体重,延长胃排空的时间,加快肠内容物移动速度,促进胆汁分泌,升高血浆CCK含量。结论SMPS降低体重的有效机制可能与其升高血浆CCK含量,使胃排空时间延长,食欲降低,肠蠕动加速,排便数量增加有关。

Aim To study mechanisms of Stigma Maydis Polysaccharide （SMPS） on weight loss in experimental animals. Methods Observe changes of gastric discharge, intestinal peristalsis, biliary secretion, weight of gallbladder, body weight, appetite and cholecystokinin（CCK） level in plasm of rats and mice after being administrated with SMPS. Results SMPS increased the gastric residual rate of methyl orange and the intestinal propulsive rate, advanced first time black dejecta, increased the quantity of dejecta, decreased the weight of gallbladder in mice. SMPS also inhibited appetite, decreased body weight, prolonged gastric emptying, accelerated the propulsion speed of intestinal contents, promoted the biliary secretion, increased CCK level in plasm. Conclusion Mechanisms of weight loss are probably related to the increasing of CCK level in plasm and prolonging of gastric emptying, appetite inhibition, accelerating of intestinal peristalsis, the quantity increasing of dejecta.