甲状腺乳头状癌多发病灶的克隆起源研究进展

Advancement of clonal origin in multifocal papillary thyroid carcinoma

多发病灶是甲状腺乳头状癌的临床特征之一，多灶比例约为18％～87％。但多灶来源于肿瘤腺内转移还是各自独立起源仍有争议。通过对RET／PTC基因重排、BRAF^V600E基因突变及X染色体失活类型的研究已表明，有相当一部分多发病灶是多克隆起源的。

The presence of multiple foci is one of the common clinical features of papillary thyroid carcinoma, frequency of muhifocal tumors ranges from 18% to 87%, But whether these foci arise from intraglandular metastases or derive from independent precursors is unsettled, Studies of RET/PTC gene rearrangements, BRAF^V600E gene mutation and patterns of X-chromosome inactivation have suggested independent clonal origin of distinct tumor foci in a significant portion of muhifocal papillary thyroid carcinoma.