颌面部创伤早期LPO与SOD的改变及维生素C抗氧化治疗的实验研究

Study On Early Variation Of LPO,SOD Following Maxillofacial Wound And Antioxidant Role Of Vitamin C

本文报告了对７８只大白鼠同１２只家兔人工创伤颌面部软组织及使下颌骨粉碎性骨折。动态观察伤前及伤后３０分钟，１、２、４、６及１２小时的ＬＰＯ、ＳＯＤ的改变。检测创伤后不论在血中，创伤组织或肝组织中，均为ＬＰＯ上升，ＳＯＤ下降，ＳＯＤ／ＬＰＯ比值下降。受伤早期大剂量使用维生素Ｃ抗氧化治疗，能够抑制ＬＰＯ的合成，增加ＳＯＤ／ＬＰＯ的比值，并能提高机体的代偿能力，对机体的结构组织有一定的保护作用。作者对创伤后ＬＰＯ改变的临床意义、ＳＯＤ的作用机制、抗氧化治疗及维生素Ｃ的应用价值等问题进行了讨论。

In the experiment,there are 78 white rats and 12 rabbits wounded to produce the maxillofacial wounds and mandibular splintered fracture models. The pathological damages of muscle in wounds and liver were studied with light microscopy in different interval (before, and after wound 30 min, 1,2,4,6,12h),as well as the variations of LPO,SOD in blood and in the tissues were also measured. The results showed that the pathological characteristics of tissue injuried were hemorrhage, oedema and degeneration. The quantity of LPO were increased obviously,SOD and the ratio of SOD/LPO decreased. In the early stage of wound prescribe vitamin C as antioxidant could restrain composition of LPO, increase SOD/LPO and the ability of restitution of organism. The clinical significance of variation in free radicals, the value of vitamin C as antioxidant was also discussed in the article.