摘要
近年来,以癫痫发生期出现的一系列神经生物学改变为靶点,从保护神经元、抑制苔藓纤维出芽、干预胶质细胞相关分子、炎症免疫等角度,已开展了大量实验研究,旨在预防癫痫。本文对此进行综述。
出处
《国际神经病学神经外科学杂志》
2007年第4期319-322,共4页
Journal of International Neurology and Neurosurgery
基金
国家自然科学基金青年科学基金(30500172)
参考文献25
-
1Jutila L, Immonen A, Partanen K, et al. Neurobiology of epileptogenesis in the temporal lobe. Adv Tech Stand Neurosurg, 2002, 27: 5-22.
-
2Fisher A, Wang X, Cock HR, et al. Synergism between topiramate and budipine in refractory status epilepticus in the rat. Epilepsia, 2004, 45(11) : 1300-1307.
-
3Pitkanen A, Kubova H. Antiepileptic drugs in neuroprotection. Expert Opin Pharmacother, 2004 , 5 ( 4 ) : 777-798.
-
4Majak K, Pitkanen A. Do seizures cause irreversible cognitive damage? Evidence from animal studies. Epilepsy Behav, 2004, 5(1) : 35-44.
-
5Fisher A, Wang X, Cock H R, et al. Synergism between topiramate and budipine in refractory status epilepticus in the rat. Epilepsia, 2004, 45(11) : 1300-1307.
-
6Brandt C, Potschka H, Loscher W, et al. N-methyl-D-aspartate receptor blockade after status epilepticus protects against limbic brain damage but not against epilepsy in the kainate model of temporal lobe epilepsy. Neuroscience, 2003, 118(3) : 727-740.
-
7Li T, Fan Y, Luo Y, et al. In vivo delivery of a XIAP (BIR3-RING) fusion protein containing the protein transduction domain protects against neuronal death induced by seizures. Exp Neurol, 2006, 197(2) : 301-308.
-
8Binder DK, Croll SD, Gall CM, et al. BDNF and epilopsy : too much of a good thing? Trends Neurosci, 2001, 24 (1) : 47-53.
-
9Lahteinen S, Pitkanen A, Koponen E, et al. Exacerbated status epilepticus and acute cell loss, but no changes in epileptogenesis, in mice with increased brain-derived neurotrophic factor signaling. Neuroscience, 2003, 122 ( 4 ) : 1081-1092.
-
10Vezzani A, Michalkiewicz M, Michalkiewicz T, et al. Seizure susceptibility and epileptogenesis are decreased in transgenic rats overexpressing neuropeptide Y. Neuroscience, 2002, 110(2) : 237-243.
同被引文献3
-
1宋治,张如旭,陈阳美.对癫痫治疗的思考——源于避雷针的启示[J].医学与哲学,1998,19(9):476-478. 被引量：4
-
2李庆昌,姚秀珍,齐根朝.微电极治疗癫痫——避雷针原理在癫痫上的应用[J].立体定向和功能性神经外科杂志,2002,15(3):184-184. 被引量：4
-
3夏杰,陈阳美.难治性癫痫与信号转导[J].国外医学（神经病学．神经外科学分册）,2004,31(1):64-67. 被引量：8
-
1伊文.头部外伤后药物预防癫痫可能有效[J].现代医院,2015,15(11):126-126.
-
2金鹤.预防癫痫发作的护理干预[J].社区卫生保健,2004,3(4):282-283.
-
3苏庆杰.脑缺血再灌注损伤的炎症免疫机制研究[J].国外医学（内科学分册）,2001,28(8):352-354. 被引量：2
-
4张开宇.老年急性脑梗死患者脑电图异常与癫痫发作的关系[J].中国实用医药,2016,11(16):120-121. 被引量：11
-
5王宇卉,邵福源.癫痫药物治疗现状与未来[J].中华国际医学杂志,2004,4(2):79-82.
-
6施晓莉.老年急性脑梗死患者脑电图异常与癫痫发作的关系[J].中国老年学杂志,2015,35(13):3612-3613. 被引量：27
-
7温玉梅,王薇薇,吴逊.癫痫患者出现新发作类型的临床研究[J].中华神经科杂志,2010,43(1):31-34.
-
8王云霞,孙来花.脑卒中后继发癫痫的护理[J].中国医学创新,2010,7(1):119-119. 被引量：6
-
9吴映曼,蔡毅.急性脑梗塞患者血清肿瘤坏死因子-α的变化[J].中国热带医学,2010,10(9):1110-1111. 被引量：8
-
10韩世伟,赵义,任吉祥.乌司他丁联合醒脑静治疗急性脑出血的疗效研究[J].广州中医药大学学报,2015,32(1):19-22. 被引量：13
