咪达唑仑用于急诊危重患者所致低血压的相关性分析

Correlation analysis of hypotension caused by midazolam in the critical patients

目的研究咪达唑仑用于急诊危重患者时所致低血压与年龄、性别、APACHEⅡ评分的相关性。方法将收入ICU的急诊危重患者按年龄分成65岁以下组(A组)和>65岁组(B组),两组患者均在气管插管前给予咪达唑仑0.2mg/kg在30s内静脉注入,随后芬太尼0.2μg/kg静脉注入,待患者入睡后行经鼻气管插管。记录插管前和插管后10min心率(HR)及血压(BP)的变化,并进行统计学处理。然后根据有无低血压重新分组,并就低血压与年龄、性别、APACHEⅡ评分等进行相关性分析。结果A组和B组用咪达唑仑后血压下降明显(P<0.01)。组间比较无统计学意义。咪达唑仑用于急诊危重患者时所致低血压与年龄、性别、APACHEⅡ评分进行相关性分析,差异无统计学意义(P>0.05)。结论咪达唑仑用于急诊危重患者时所致低血压与年龄、性别、APACHEⅡ评分无相关性。

Objective To study the correlation between the hypotension caused by midazolam in critical patients and age, sex, APACHE Ⅱ. Methods The critical patients admitted into the ICU were divided into two groups according to age, group A （ 〈65years old, n =20） and group B （ 〉65 years old, n =21 ）. All the patients received intravenous midazolam 0.2 mg/kg in 30 seconds and intravenous fentanyl 0.2 μg/kg, and nasal intubation was performed when they fell asleep. The changes of systolic blood pressure, diastolic blood pressure, heart rate and blood oxygen saturation were recorded 10 minutes before intubation and after intubation for statistical analysis. The patients were divided into two groups again ： hypotension group and normal blood pressure group. Correlation analysis between age, sex, APACHE Ⅱ and hypotension was made. Results Group A and group B before and after medication had significant changes in blood pressure（ P 〈0.01 ）, but there was no statistical significance between the two groups. There was no statistical significance between the hypotension caused by midazolam in critical patients and age, sex, APACHE Ⅱ（ P 〉 0.05 ）. Conclusion There is no correlation between hypotension caused by midazolam in critical patients and age, sex, APACHE Ⅱ.