联合草酸铂经动脉介入治疗晚期胃癌疗效观察

Arterial interventional therapy of advanced gastric cancer with oxaliplatin

目的对比观察经介入动脉应用草酸铂的联合方案治疗晚期胃癌的疗效和毒副反应。方法采用介入方法插管留置化疗,加热灌注草酸铂等化疗药物后局部栓塞治疗,对部分肝转移灶结合微波治疗,与相同方案的全身静脉化疗比较。结果经动脉介入化疗的观察组与全身静脉化疗组在有效率、中位生存期方面差异有显著性(P(0.05)。化疗的毒副反应主要表现为恶心、呕吐及腹痛、腹泻,观察组较对照组稍重,其他方面差异无显著性。结论应用草酸铂等化疗药物对晚期胃癌经动脉介入热化疗,结合栓塞血管治疗是一种有效、安全的方法。

Objective To evaluate the efficacy and toxicity of L-OHP combined with 5-fluorouracil/ calcium folinate （5-Fu/CF） in interventional therapy of advanced gastric cancer. Methods Percutaneous puncture of artery and port-catheter system （PCS） implantation were carried out in 18patients with advanced gastric cancer. These patients were treated with intraarterial chemotherapy with L-OHP（ observation group）. Other 25 patients were treated with intravenous injection of the same anticancer agents（ control group）. Resuits The total effective rate and the median survival time of observation group were higher than those of the control group（ P 〈 0.05 ）. The toxic side effects of the chemotherapy were mainly nausea, vomiting, abdominal pain and diarrhea, which were more severe in observation group than in control group. Other aspects had no significant difference. Conclusion The interventional therapy with oxaliplatin is an effective and safe method for advanced gastric cancer.