摘要
Chronic viral infections such as hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) are major global health problems affecting more than 500 million people worldwide. Virus-specific CD8+ T cells play an important role in the course and outcome of these viral infections and it is hypothesized that altered or impaired differentiation of virus- specific CD8+ T cells contributes to the development of persistence and/or disease progression. A deeper understanding of the mechanisms responsible for functional differentiation of CD8+ T cells is essential for the generation of successful therapies aiming to strengthen the adaptive component of the immune system.
Chronic viral infections such as hepatitis B virus （HBV）, hepatitis C virus （HCV） and human immunodeficiency virus （HIV） are major global health problems affecting more than 500 million people worldwide. Virus-specific CD8＋ T cells play an important role in the course and outcome of these viral infections and it is hypothesized that altered or impaired differentiation of virus-specific CD8＋ T cells contributes to the development of persistence and/or disease progression. A deeper understanding of the mechanisms responsible for functional differentiation of CD8＋ T cells is essential for the generation of successful therapies aiming to strengthen the adaptive component of the immune system.
基金
NIH National Center for Research Resources K12 RR017643 and NIH K08 AI072191 (HR)
the National Institutes of Health through the Grand Challenges in Global Health Initiative, Cancer Research Institute Investigator Award, Woodruff Health Sciences Fund, Yerkes Research Center Base Grant RR-00165 and NIH AI070101 (AG)
关键词
丙型肝炎
病毒感染
记忆T细胞表型
分化
Viral infection
Hepatitis C virus
Memory T cell phenotype
Differentiation
