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Secondary pancreatic involvement by a diffuse large B-cell lymphoma presenting as acute pancreatitis 被引量:4

Secondary pancreatic involvement by a diffuse large B-cell lymphoma presenting as acute pancreatitis
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摘要 Diffuse large B-cell lymphoma is the most common type of non-Hodgkin's lymphoma. More than 50% of patients have some site of extra-nodal involvement at diagnosis, including the gastrointestinal tract and bone marrow. However, a diffuse large B-cell lymphoma presenting as acute pancreatitis is rare. A 57-year-old female presented with abdominal pain and matted lymph nodes in her axilla. She was admitted with a diagnosis of acute pancreatitis. Abdominal computed tomography (CT) scan showed diffusely enlarged pancreas due to infiltrative neoplasm and peripancreatic lymphadenopathy. Biopsy of the axillary mass revealed a large B-cell lymphoma. The patient was classified as stage Ⅳ, based on the Ann Arbor Classification, and as having a high-risk lymphoma, based on the International Prognostic Index. She was started on chemotherapy with CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone). Within a week after chemotherapy, the patient’s abdominal pain resolved. Follow-up CT scan of the abdomen revealed a marked decrease in the size of the pancreas and peripancreatic lymphadenopathy. A literature search revealed only seven cases of primary involvement of the pancreas in B-cell lymphoma presenting as acute pancreatitis. However, only one case of secondary pancreatic involvement by B-cell lymphoma presenting as acute pancreatitis has been published. Our case appears to be the second report of such a manifestation. Both cases responded well to chemotherapy. Diffuse large B-cell lymphoma is the most common type of non-Hodgkin's lymphoma. More than 50% of patients have some site of extra-nodal involvement at diagnosis, including the gastrointestinal tract and bone marrow. However, a diffuse large B-cell lymphoma presenting as acute pancreatitis is rare. A 57-year-old female presented with abdominal pain and matted lymph nodes in her axilla. She was admitted with a diagnosis of acute pancreatitis. Abdominal computed tomography (CT) scan showed diffusely enlarged pancreas due to infiltrative neoplasm and peripancreatic lymphadenopathy. Biopsy of the axillary mass revealed a large B-cell lymphoma. The patient was classified as stage Ⅳ, based on the Ann Arbor Classification, and as having a high-risk lymphoma, based on the International Prognostic Index. She was started on chemotherapy with CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone). Within a week after chemotherapy, the patient’s abdominal pain resolved. Follow-up CT scan of the abdomen revealed a marked decrease in the size of the pancreas and peripancreatic lymphadenopathy. A literature search revealed only seven cases of primary involvement of the pancreas in B-cell lymphoma presenting as acute pancreatitis. However, only one case of secondary pancreatic involvement by B-cell lymphoma presenting as acute pancreatitis has been published. Our case appears to be the second report of such a manifestation. Both cases responded well to chemotherapy.
出处 《World Journal of Gastroenterology》 SCIE CAS CSCD 2007年第36期4909-4911,共3页 世界胃肠病学杂志(英文版)
关键词 Non-Hodgkin's lymphoma Acute pancreatitis Pancreatic lymphoma 急性胰腺炎 非霍奇金淋巴瘤 胰腺淋巴瘤 治疗方法
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参考文献12

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同被引文献17

  • 1刘思德,姜泊,周殿元.肠病型T细胞淋巴瘤内镜典型形态——附6例临床分析[J].现代消化及介入诊疗,2004,9(2):114-118. 被引量:13
  • 2王焱,周晓军,石群立,黄文斌,周航波,马捷,陈洁宇,马恒辉.原发性胃肠道淋巴瘤的临床病理研究[J].中华消化杂志,2006,26(7):491-492. 被引量:28
  • 3卢晓云,李运红,刘明东,张建武,吕瑛,陈隆典,徐肇敏,邹晓平.原发性胃肠道恶性淋巴瘤33例临床分析[J].中华消化内镜杂志,2006,23(6):433-435. 被引量:16
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