高锌摄入对四氧嘧啶糖尿病小鼠的影响

The Effects of High Dietary Zinc on Alloxan Induced Diabetic Mice

本文观察了高锌摄入对四氧嘧啶诱发小鼠糖尿病的影响，结果显示：饲以高锌可加速、加重小鼠糖尿病的发病，与糖尿病模型组相比，体重明显减轻，饮水量、食量及尿量增多，尿糖升高迅速，空腹血糖较高，提示临床糖尿病患者补锌应慎重考虑剂量。

The effects of high dietary zinc on alloxan induced diabetic mice were studied. The results showed that high zinc could sharply decrease the body weight and increase food intake, water intake and urine of diabetic mice, and increase blood sugar levels in diabetic mice.After alloxan injection in diabetic model group, urine sugar levels reached  at the 2nd day and  at the 6th day. After alloxan injection in high zinc diabetic mice group, urine sugar levels reached  and  at the 2nd and the 4th day, respectively. These results suggested that the high level of dietary zinc may be damage to diabetic patients.