6,7-二氢-5H-环戊烷并[b]吡啶的合成研究

Study On the Synthesis of 6,7-Dihydro-5H-cyclopentano[b]pyridine

以环戊酮和丙炔胺为原料,在高压釜中用氯化亚铜催化合成头孢匹罗关键中间体6,7-二氢-5H-环戊烷并[b]吡啶。研究了催化剂及其用量、反应温度、反应溶剂等对反应收率的影响,得到GC纯度>99%的产品,收率高于60%。

6,7-Dihydro-5H-cyclopentano[b]pyridine, a key intermediate of Cefpirome, was synthesized from cyclopentanone and propargylamine under autoclave prompted by copper（l） chloride. The optimum processing parameters such as catalysts, catalytic amounts, temperatures and solvents were investigated. The product yield is over 60% and the GC purity is over 99%.