N-丙基-4-哌啶酮的合成研究

Study on the Synthesis of N-Propyl-4-piperidone

以丙烯酸甲酯和丙胺为原料,经过Michael加成,Dieckmann缩合和水解脱羧反应,简便、高效地合成了N-丙基-4-哌啶酮。分别对原料配比、合成过程等方面进行了改进,简化了合成工艺,节省了原料和成本,更适合于大规模生产。产品经过核磁氢谱检测表征,而且也经过气相色谱检测,具有很高的纯度。

N-Propyl-piperidone was synthesized with propylamine and methyl acrylate as raw materials via a series of Michael addition, Dieckmann condensation and hydrolysis decarboxylation reactions. The proportion of materials and the synthetic condition were optimized. The product was characterized by elemental analysis, GC and ^1H NMR.