液基薄层细胞学技术联合阴道镜检查筛查宫颈病变的临床研究

Clinical study of thinprep cytologic test(TCT) combined with biopsy under colposcpy in diagnosis of cervical squamous intraepithelial lesions

目的探讨液基薄层细胞学技术(TCT)联合阴道镜下组织病理学检查对宫颈病变筛查的临床应用价值。方法选择妇科门诊519例临床可疑患者进行宫颈病变筛查,其中268例妇女做TCT检查联合阴道镜活检(实验组),251例直接阴道镜检查活检(对照组),最终均以组织学诊断为金标准,比较两组组织学诊断阳性符合率。结果实验组组织学诊断阳性符合率为72.0%(193/268),对照组为50.1%(126/251),两组诊断符合率比较差异有统计学意义(χ2=388.62;P<0.005)。结论TCT技术联合阴道镜活检,能提高宫颈瘤变的阳性诊断率,是筛查和诊断子宫颈病变的可靠手段。

Objective To investigate the effectiveness of thinprep cytologic test （TCT）combined with biopsy under colposcopy for diagnosis of cervical squamous intraepithelial lesions （CIN）. Methods 519 suspicious patients were assigned to receive TCT combined with biopsy under colposcopy（TCT group,268 patients） or biopsy under colpascopy randomly （control group ,251 patients ）. Pathologic examination of biopsy sample was used as gold standard. Results The coincidence on diagnosis of cervical lesions between TCT group and pathologic examination of biopsy sample was 72.0% （ 193/268 ）, the coincidence on diagnosis of cervical lesions between control group and pathologic examination of biopsy sample was 50. 1% （ 126/251 ） ,the difference was significant （ x^2 = 388.62,P 〈 0. 005）. Conclusion TCT combined with biopsy under colposcopy may be a reliable method to screen and diagnose the precancerosis of cervix.