N-(1-异丙基-2-羧基-4-甲基二环[2.2.2]-5-辛烯-3-羰基)-N′-芳基(硫)脲的合成

Synthesis of N-(1-isopropyl-2-carboxyl-4-methylbicyclo[2.2.2]-oct-5-en-3-carbonyl)-N′-aryl(thio)ureas

在无溶剂绿色化学条件下,将α-萜品烯-马来酸酐加成物(1)与取代苯(硫)脲发生N-酰化反应,合成了4个N-(1-异丙基-2-羧基-4-甲基二环[2.2.2]-5-辛烯-3-羰基)-N′-芳基(硫)脲化合物(3a^3d),并由IR、UV-Vis、MS、1HNMR、13C NMR和元素分析确认了目标产物的结构。生物活性测试表明,其中3个化合物(3a、3b和3c)具有植物激素作用。

Four novel compounds, N-（1-isopropyl-2-carboxyl-4-methylbicyclo [2.2.2]-oct-5-en-3-carbonyl）-N＇-aryl （thio）ureas （3a- 3d）, were synthesized by the N-acylation reaction of α-terpinene-maleic anhydride adduct（1） with substituted phenyl （thio） ureas under solvent-free green chemistry conditions and characterized by means of IR, UV-vis, MS, ^1 H NMR, ^13 C NMR and elemental analysis. The biological tests indicated that compounds 3a, 3b and 3c exhibit plant hormone activities.