氯硝柳胺衍生物的合成与结构表征

Synthesis and Characterization of Niclosamide Derivatives

由氯硝柳胺与1,2-二溴乙烷反应,得到2-(2-溴乙氧基)-5-氯-N-(2-氯-4-硝基苯基)苯甲酰胺,再与乙二醇、二乙二醇、三乙二醇分别反应,得到了三个氯硝柳胺衍生物,其结构由IR1、H NMR和高分辨质谱确证。

Three niclosamide derivatives were synthesized through the reaction of 2- （2-bromoelhoxy）-5-chloro- N- （2- chloro-4-nitrophenyl） benzamide, which was obtained by the reaction of niclosamide with 1,2-dibromoethane, with glycol, diethylene glycol,triethylene glycol, respectively. They had been confirmed by IR, ^1H NMR and HR-EIMS.