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流行性乙型脑炎DNA疫苗增强效应研究进展 被引量：1

Progress in Enhanceing Effect of Japanese Encephalitis DNA Vaccine
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摘要 流行性乙型脑炎(JE)DNA疫苗免疫的效果已得到证实,但同现有JE灭活或减毒疫苗的免疫效果比较,JEDNA疫苗诱导的中和抗体产生的时间、抗体效价增长速度及效价绝对值还达不到预期标准。如何提高JEDNA疫苗免疫的效果,各种增强效应的研究成为近年研究的热点。该文就如何提高JEDNA疫苗增强效应的研究进展作一综述。
作者 翟永贞 冯国和
机构地区 中国医科大学附属盛京医院感染科
出处 《国际儿科学杂志》 2007年第5期319-322,共4页 International Journal of Pediatrics
基金 国家自然科学基金资助项目(30471547) 教育部留学回国人员启动基金(教外司留[2004]527) 辽宁省自然科学基金资助项目(20042072) 辽宁省教育厅重大基础研究计划(05L498)
关键词 脑炎 日本 疫苗 DNA 增强效应
分类号 R392 [医药卫生—免疫学]
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参考文献25

  • 1Feng GH, Takegami T, Zhao G, Characterization and E protein expression of mutant strains during persistent infection of KN73 cells with Japanese encephalitis virua[J]. Chin Med J, 2002,115(9) : 1324-1327.
  • 2Bharati K, Appaiahgari MB, Vrati S. Effect of Cytokine-encoding plasmid delivery on immune response to Japanese Encephalitis virus DNA vaccine in mice[J] .J Microbiol Immunol,2005,49(4) :349-353.
  • 3Yoon HA, Aleyas A, George JA, et al. Cytokine GM-CSF genetic adjuvant facilitates prophylactic DNA vaccine against pseudorabies virus through enhanced immune responses[J]. Microbiol Immunol,2006,50(2):83-92.
  • 4Saldarriaga OA, Perez LE, Travi BL, et al. Selective enhancement of the type 1 cytokine response by expression of a canine IL-12 fused heterodimeric DNA[J]. Vet Immunol Immunopathol,2006,110(3-4) : 377-388.
  • 5Chen HW,Pan CH,Huan HW, et al.Suppression of immune response and protective immunity to a Japanese encephalitis virus DNA vaccine by coadministration of an IL-12-expressing plasrnid[J]. J Immunol,2001,166 (12) :7419-7426.
  • 6Rompato G,Ling E, Van Kruiningen H, et al. Positive inductive effect of IL-2 on virus-specific cellular responses elicited by a PRRSV-ORF7 DNA vaccine in swine [ J ]. Vet Immunol Immunopathol, 2006, 109 ( 1-2 ) : 151-160.
  • 7Wienhold D, Armengol E, Marquardt A, et al. Immunomodulatory effect of plasmids co-expressing cytokines in classical swine fever virus subunit gp55/E2-DNA vaccination[J]. Vet Res,2005,36(4) :571-587.
  • 8Jin HT,Youn JI, Kim HJ,et al. Enhancement of interleukin-12 gene-based tumor immunotherapy by the reduced secretion of p40 subunit and the combination with famesyltransferase inhibitor[J]. Hum Gene Ther,2005, 16 (3) : 328-338.
  • 9Manoj S, Babiuk LA, van Drunen Littel-van den Hunk S. Immunization with a dicistronic plasmid expressing a truncated form of bovine herpesvirus-1 glycoprotein D and the amino-terminal subunit of glycoprotein B results in reduced gB-specific immune responses [ J ]. Virology, 2003,313 ( 1 ) : 296- 307.
  • 10Purdy D, Chang G. Secretion of noninfectious dengue virus-like particles and identification of amino acids in the stem region involved in intracellular retention of envelope protein[J]. Virology,2005,333(2) :239-250.

同被引文献8

  • 1Putnak R,Porter K, Schmaljohn C. DNA vaccines for flaviviruses[J]. Adv. Virus Res, 2003,61 : 445-468.
  • 2Wu HH, Chen CT, Lin YL, et al. Sub-fragments of the envelope gene are highly protective against the Japanese encephalitis virus lethal infection in DNA prlming-protein boosting immunization strategies [ J ]. Vaccine, 2004,22(5-6) : 753-800.
  • 3Zhao Z, Wakia T, Yasui K. Inoculation of plasmids encoding Japanese encephalitis virus-prM-E pritains with colloidal gold elicits a protective immune response in BALB/c mice [J]. J Virol,2003,77 (7) :4248- 4260.
  • 4Ashok MS, Rangarajan PN. Protective efficacy of a plasmid DNA encoding Japanese encephalitis virus envelope protein fused to tissue plasminogen activator signal sequences:studies in a routine intracerebral virus challenge model[J].Vaccine, 2002,20 ( 11-12) : 1563- 1570.
  • 5Bharati K,Appaiahgari MB,Vrati S. Effect of Cytokine-encoding plasmid delivery on immune response to Japanese encephalitis virus DNA vaccine in mice[J]. Microbiol Immunol, 2005,49(4) :349-353.
  • 6Feng GH,Liu N,Zhou Y,et al. Immunologic analysis induced by DNA vaccine encoding E protein of Beijing-1 strain derived from Japanese encephalitis virus [ J ]. Intervirology, 2007,50 (2) : 93-98.
  • 7Wang J,Snider DP,Hewlett BR,et al. Transgenic expression of granulocyte-macrophage colony-stimulating factor induces the differentiation and activation of a novel dendritic cell population in the lung[J]. Blood, 2000,95 (7) : 2337-2345.
  • 8冯国和,赵桂珍,竹上勉,窦晓光,乔光彦,周子文.乙脑病毒prME与E蛋白编码基因重组构建的DNA免疫试验研究[J].中华微生物学和免疫学杂志,2002,22(5):505-509. 被引量：7

引证文献1

国际儿科学杂志
2007年 第5期

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