中医药治疗绝经综合征的临床证据

Clinical Evidence on Traditional Chinese Medicine for Menopausal Syndrome

目的总结国内外有关中医药治疗绝经综合征的系统评价/Meta分析证据,了解其疗效和安全性。方法以"更年期综合征、绝经综合征、围绝经期综合征"和"中医、中药、中医药"和"系统评价、Meta分析、循证医学"为检索词,检索Cochrane图书馆(2006年第4期)、MEDLINE(1991～2006)、OVID(1990～2006)、中国生物医学文献光盘(1990～2006)、中文科技期刊数据库(1989～2006)、中国学术期刊全文数据库(1979～2006)。查找有关中医药治疗绝经综合征的系统评价/Meta分析。结果外文数据库共检索到4篇,中文数据库共检索到2篇,均为中医药治疗绝经综合征的系统评价/Meta分析,对6篇文献进行归纳和总结。结论中医药治疗绝经综合征有一定的疗效,且安全性较高。但由于国外研究多为单味药研究,且研究数量偏少;国内研究的原始文献质量偏低等原因,降低了上述结论的可靠性,因此目前中医药对于绝经综合征的疗效及安全性的证据尚不够充分,尚需更严谨科学的试验以提供可靠性高的证据。

Objective To review the systematicreviews/ meta-analyses involving Traditional Chinese Medicine （TCM ） therapy for menopausal syndrome, so as to offer clinical evidence about the safety and efficacy of TCM. Methods We searched The Cochrane Library （Issue 4, 2006）, MEDLINE （1991 to 2006）, Ovid （1990 to 2006）, CBM（1990 to 2006）, CNKI（1989 to 2006） and VIP（1979 to 2006）. The search terms of ＂menopause OR climacteric＂ and ＂traditional Chinese medicine OR herb OR plant＂ and ＂systematic review OR evidence-based medicine OR Meta-analysis OR Metaanalysis＂ were used to identify systematic reviews or metaanalyses on TCM for menopause syndrome. Results A total of 6 systematic reviews or meta-analyses were identified. Two of these were in Chinese databases and four were in the foreign language databases. The 6 articles were reviewed and summarized. Conclusion TCM has a effect in the treatment of menopausal syndrome with a good safety profile. However, due to the generally low quality of included studies, the evidence available is not strong enough to evaluate the efficacy and safety of TCM for menopausal syndrome. More rigorously designed and strictly executed trials are needed.