p63蛋白在食管磷状细胞癌中的表达及意义

Expression And Significance of p63 Protein In Esophageal Squamous Cell Carcinoma

目的检测p63蛋白在食管癌组织中的表达情况,并探讨其与食管癌临床病理特征的关系。方法采用免疫组化检测p63蛋白在53例食管磷癌及癌旁组织中的表达情况。结果p63蛋白在食管癌组织中的阳性表达率为71.7%(38/53),而在癌旁食管组织中的阳性表达率为35.8%(19/53),两者比较有显著性差异(P<0.01)。p63蛋白的表达与食管磷癌分化程度密切相关(P<0.05),其在低分化磷癌中的阳性表达率(89.5%)显著高于在高分化磷癌中的阳性表达率(46.2%)。p63蛋白的表达与食管磷癌的TNM分期、淋巴结转移、浸润深度均无明显相关性(P>0.05)。结论p63蛋白在食管磷癌组织中呈高表达,表明其可能参与食管磷癌的发生发展。

Objective To investigate the expression of p63 protein in esophageal squamous carcinoma and its clinicopathologic significance.Methods Immunohistochemical method was used to detect the expression of p63 from the squamous esophageal cancer tissues and pericancerous epithelia tissues in 53 cases.Results The positive expression rates of p63 in the squamous esophageal cancer tissues and pericancerous epithelia tissues in 53 cases was 71.7%（38/53） and 35.8%（19/53） respectively.The rates were significantly different from each other（ P〈0.01）.Furthermore,the expression of p63 was closely correlated with the differentiation degree（P〈0.05）： the positive rate of p63 in poor differentiation esophageal carcinoma（89.5 %）was notablely higher than well differentiation esophageal carcinoma（46.2 %）.But the expression of p63 was not significantly correlated with the TNM stage,lymph node metastasis,and infiltrative depth（P〉0.05）.Conclusion The expression of p63 in esophageal squamous carcinoma tissues is high,which suggested that it may involve in esophageal squamous carcinogenesis.