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枯草芽孢杆菌基因组知识的生物学意义及对生物工程学的影响 被引量:1

New information of the Bacillus subtilis genome and effect on biology and biotechnology
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摘要 基因组学的出现极大地影响了微生物学的基础研究和应用研究.枯草芽孢杆菌(Bacillus subtilis)是一个用于基础研究和生物工艺研究的重要模式细菌.从它的基因组获得的知识远比长期以来用传统的方法获得的信息要多.通过先进的方法分析其基因组和转录组,基本弄清了关于枯草芽孢杆菌染色体结构的信息,已经达到了能够阐明其基因表达过程的水平,使得完全掌握枯草芽孢杆菌分泌途径的生物化学操作成为可能,这将成为生物工艺学的重大成果.在理论上,随着对它的分析越来越细致,已经阐明一个遗传学的海量信息的新观念,直至获得理解再造一个细胞所需的最小的基因组的知识.总之,枯草芽孢杆菌基因组知识已经明显地更新了基础知识向应用微生物学和生物工艺学转化的途径,并使这种细菌成为后基因组微生物学的重要工具. The purpose of this review is to focus on the most recent progress related to the functional analysis of the Bacillus spp. genomes, with a particular attention to B. subtilis, pointing out their revolutionary impact on scientific know -how and industrial applications. Furthermore, some new conclusions on the biological meaning of DNA secondary structures are provided within the framework of this novel, in - depth type of genome analysis.
作者 刘秀花
出处 《商丘师范学院学报》 CAS 2007年第9期99-103,114,共6页 Journal of Shangqiu Normal University
基金 河南省教育厅自然科学基金项目(项目编号:200510483001) 河南省科技攻关项目(项目编号:424240005)资助
关键词 芽孢杆菌 基因组 转录组 生物工程 Bacillus spp genome transcriptome biotechnology
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