贵阳市社区老年人群阿尔茨海默病危险因素病例对照研究

A CASE-CONTROL STUDY ON RISK FACTORS OF ALZHEIMER’S DISEASE IN THE ELDERLY IN URBAN COMMUNITY OF GUIYANG

[目的]探讨贵阳市社区老年人阿尔茨海默病患病(AD)的危险因素。[方法]采用以人群为基础按1︰4比例进行年龄、性别匹配的病例对照研究,病例为调查的样本人群中确诊的AD患者36例,对照为同人群中符合匹配条件的认知功能正常者144例。用SPSS10.0软件进行单因素分析和条件Logistic回归分析。[结果]工具性日常生活功能(IADL)下降者患AD的危险性较高(OR:5.23,95%CI:1.59～17.14)。较长的教育年限、积极参加集体活动、长期服用抗高血压药物者患AD的危险性较低,其OR值分别为0.06(95%CI:0.00～0.58)、0.14(95%CI:0.04～0.52)和0.01(95%CI:0.00～0.13)。[结论]IADL降低可能是AD的危险因素,而教育年限、积极参加集体活动、长期服用抗高血压药物对AD可能具有保护作用。

[Objective]To study the risk factors of Alzheimer’s disease in the elderly in urban community of Guiyang.[Methods]A population based,1︰4 matched case-control study was conducted,including 36 AD patients from sample population as cases and 114 non-cognitive impairment individuals from the same population matched for age and sex as controls. data were analyzed using univariate analysis and conditional logistic regression analysis with SPSS10.0 software.[Results]The subjects whose IADL（Instrument Activities of Daily Living）declined had a higher risk of AD,and OR was 5.23（95%CI：1.59-17.14）. However,the people who received more education,positively participated in the collective activities and took anti-hypertension medicines for a long time had a lower risk,and OR were 0.06（95%CI：0.00-0.58）,0.14（95%CI：0.04-0.52）and 0.01（95%CI：0.00-0.13）respectively.[Conclusion]The function disability for IADL may be a risk factor for AD,but more education,positively participated in collective activities and using anti-hypertenstion drugs for a long time may be the protect factors.