雄激素非依赖性前列腺癌介入治疗的临床观察(附23例报告)

Internal iliac artery chemotherapy for the treatment of androgen-independent prostate cancer

目的:观察经髂内动脉灌注化疗治疗雄激素非依赖性前列腺癌(Androgen-independent prostate cancer,AIPC)的临床疗效。方法:将38例已确诊为AIPC患者按治疗时间先后随机分为介入治疗组与对照组,其中介入治疗组23例在内分泌治疗(药物加手术去势),同时行双侧髂内动脉定期灌注化疗;对照组15例采用内分泌治疗,观察并比较二者疗效。结果:介入治疗组临床症状明显减轻,最大尿流率在治疗后6个月明显改善,与对照组比较差异有统计学意义,经2年随访,介入治疗组与对照组总有效率分别为65.2%与26.7%,二者相比差异有统计学意义(P<0.05)。结论:经双侧髂内动脉灌注化疗治疗AIPC疗效肯定,可显著改善患者的临床症状与生活质量。

Objective：To observe the effects of bilateral internal iliac artery infusion of chemotherapeutic agents for the treatment of androgen-independent prostate cancer （AIPC）. Methods： A total of 38 cases of patients with AIPC were randomly divided into treatment group and control group. The patients in treatment group （23 cases） were treated with androgen deprivation therapy and regular internal iliac artery infusion of chemotherapeutic agents, while the patients in control group （15 cases） were only treated with androgen deprivation. The efficiencies of the two groups were compared and analyzed when the therapies were completed. Results：The clinical symptoms and maximum flow rates of treatment group were improved rapidly 6 months later. After 2 years follow-up, the total improvement rate of the treatment group and control group were 65.2 % and 26.7 % respectively. The difference was of significance（P;0.05）. Conelt;ions： The treatment of AIPC with bilateral internal iliac artery infusion of chemotherapeutic agents is effective, it can meliorate the quality of life and alleviate symptoms of AIPC patients.