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Galectin-3蛋白在膀胱移行细胞癌中的表达及其意义 被引量：1

The expression of galectin-3 in human bladder transitional-cell carcinomas and its significance
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摘要 目的:研究Galectin-3蛋白与膀胱移行细胞癌之间的关系。方法:采用免疫组织化学二步法检测Galectin-3蛋白在膀胱移行细胞癌以及正常膀胱黏膜上的表达,并对膀胱癌组织进行系统的病理学检查和分析。结果:①膀胱移行细胞癌上的Galectin-3蛋白表达强度明显高于正常对照组(P<0.05)。②膀胱低分化移行细胞癌中Galectin-3蛋白表达高于高分化移行细胞癌。③复发的膀胱移行细胞癌中Galectin-3蛋白表达强度高于无复发的膀胱移行细胞癌。结论:①Galectin-3蛋白的表达量与膀胱移行细胞癌的恶性程度呈正相关。②Galectin-3蛋白表达量高的膀胱移行细胞癌容易复发。 Objeetive：To investigate the relationship between galectin-3 expression and the biological behavior of human bladder transitional-cell carcinomas. Methods：The expression of Galectin-3 in 94 cases of bladder transitional-cell carcinomas and 10 normal urothelium samples were evaluated immunohistochemically. Results ： （1）The expression levels of galectin-3 were increased in most tumors compared with normal urothelium, （P〈0.05）. （2）The expression of Galectin-3 in poorly differentiated tumor was higher than that in well-differentiated cancer. （3）The expression of Galectin-3 in recurring tumor was higher than that in non-recurring tumor. Conelusions：（1）The galectin- 3 could determine the degree of malignancy of human bladder transitional-cell carcinomas. （2）The bladder transitional-cell carcinomas that express higher level of galectin-3 recur easily.
作者 陈伟 张方毅 陈洪德 李叶平 黄卡特
机构地区 温州医学院附属第一医院泌尿外科 温州医学院附属第一医院病理科
出处 《临床泌尿外科杂志》 2007年第9期703-705,共3页 Journal of Clinical Urology
关键词 膀胱移行细胞癌 GALECTIN-3蛋白 复发 Bladder transitional-cell carcinomas Galectin-3 albumen Recurring
分类号 R737.14 [医药卫生—肿瘤]
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参考文献12

  • 1Liu F T, Hsu D K, Zuberi R I, et al. Expression and function of galectin-3, a beta-galactoside-binding lectin, in human monocytes and macrophages[J]. Am J Pathol, 1995, 147(4):1016.
  • 2杨志明,伍晓汀,何涛,达明绪,罗婷,钱昆.Galectin-3蛋白表达与胃癌腹膜转移关系的研究[J].中华胃肠外科杂志,2005,8(2):151-154. 被引量：3
  • 3Oka N, Takenaka Y. Galectins and urological cancer [J]. Journal of Cellular Biochemistry, 2004,91:118-124.
  • 4Baldus S E, Zirbes T K. Increased galectin-3 expression in gastric cancer:correlations with histopathological subtypes, galactosylated antigens and tumor cell proliferation[J]. Tumour Biol, 2000, 21(5):258.
  • 5llerhorst J A, Stephens L C. Effect s of galectin-3 expression on growth and tumorigenicity of the prostate cancer cell line LNCaP[J]. Prostate, 2002, 50(1) :64.
  • 6Iurisci I, Tinari N. Concentrations of galectin-3 in the sera of normal controls and cancer patients[J]. Clin Cancer Res, 2000,6(4):1389-1393.
  • 7Angia-Makker P, Honjo Y. Galectin-3 induces endothelial cell morphogenesis and angiogenesis[J]. Am J Pat Hol, 2000,156(3):899.
  • 8Matarrese P, Fusco O, Galectin3 overexpression protects from apoptosis by improving cell adhesion properties[J], Int J Cancer, 2000,85(4):545.
  • 9Warfield P R, Makker P N, Raz A, et al. Adhesion of human breast carcinoma to extracellular matrix proteins is modulated by galectin-3[J]. Invasion Metastasis, 1997, 17(2):101.
  • 10nohara H, Akahani S, Kot hs K, et al. Interactions between galectin-3 and Mac-2-binding protein mediate cell-cell adhesion[J]. Cancer Res, 1996, 56(19):4530.

二级参考文献19

  • 1Miyazaki J,Hokari R,Kato S,et al. Increased expression of galectin-3 in primary gastric cancer and the metastatic lymph nodes. Oncol Rep,2002,9:1307-1312.
  • 2Sakakura C,Hagiwara A,Nakanishi M,et al. Differential gene expression profiles of gastric cancer cells established from primary tumour and malignant ascites. Br J Cancer,2002,87:1153-1161.
  • 3Berberat PO,Friess H,Wang L,et al. Comparative analysis of galectins in primary tumors and tumor metastasis in human pancreatic cancer. J Histochem Cytochem,2001,49:539-549.
  • 4Liu FT,Hsu DK,Zuberi RI,et al. Expression and function of galectin-3,a beta-galactosidebinding lectin,in human monocytes and macrophages. Am J Pathol,1995,147:1016-1028.
  • 5Woo HJ,Shaw LM,Messier JM,et al. The major nonintegrin laminin binding protein of macrophages is identical to carbohydrate binding protein 35 (Mac-2). J Biol Chem,1990,265:7097-7099.
  • 6Inohara H,Raz A. Functional evidence that cell surface galectin-3 mediates homotypic cell adhesion. Cancer Res,1995,55:3267-3271.
  • 7Inohara H,Akahani S,Koths K,et al. Interactions between galectin-3 and Mac-2-binding protein mediate cell-cell adhesion. Cancer Res,1996,56:4530-4534.
  • 8Ohannesian DW,Lotan D,Thomas P,et al. Carcinoembrionic antigen and other glycoconjugates act as ligands for galectin-3 in human colon carcinoma cells. Cancer Res,1995,55:2191-2199.
  • 9Ochieng J,Leite-Browning ML,Warfield P. Regulation of cellular adhesion to extracellular matrix proteins by galectin-3. Biochem Biophys Res Commun,1998,246:788-791.
  • 10Matarrese P,Fusco O,Tinari N,et al. Galectin-3 overexpression protects from apoptosis by improving cell adhesion properties. Int J Cancer,2000,85:545-554.

共引文献2

同被引文献14

  • 1Ellerhorst J,Troncoso P, Xu X C, et al. Galectin-1 and galectin-3 expression in human prostate tissue and prostate cancer [ J ]. Urol Res, 1999,27 (5) :362 - 7.
  • 2Liu F T,Patterson R J, Wang J L. Intracellular functions of galec- tins [ J ]. Biochim Biophys Acta, 2002,1572 (2 - 3 ) :263 - 73.
  • 3Waalkes S, Merseburqer A S, Simon A, et al. Galectin expression in urological cancer. Diagnostic, prognostic and therapeutic poten- tial[ J]. Urologe A,2010,49 (3) :387 - 91.
  • 4Sakaki M, Oka N, Nakanishi R, et al. Serum level of galectin-3 in human bladder cancer[ J ]. J Invest,2008,55 ( 1 - 2) : 127 - 32.
  • 5Kramer M W, Kuczyk M A, Hennenlotter J, et al. Decreased ex- pression of galectin-3 predicts tumour recurrence in pTa bladder cancer [ J ]. Oncol Rep,2008,20 (6) : 1403 - 8.
  • 6Kleiner D E,Stetler-Stevenson W G. Matrix metalloproteinases and metastasis[ J]. Cancer Chemother Pharmacol, 1999 43 ( 1 ) : S42 - 51.
  • 7Liotta L A, Stetler-Stevenson W G. Tumor invasion and metastasis: an imbalance of positive and negative regulation[ J]. Cancer Res, 1991,51 (18) :5054s - 9s.
  • 8Loukopoulos P, Mungall B A,Straw R C, et al. Matrix metallopro- teinase-2 and-9 involvement in canine tumors [ J ]. Vet Pathol, 2003,40(4) :382 -94.
  • 9Oehieng J, Fridman R, Nangia-Makker P, et al. Galectin-3 is a no- vel substrate for human matrix metalloproteinases-2 and-9 [ J ]. Bio- chemistry, 1994,33 (47) : 14109 - 14.
  • 10Zucker S, Cao J, Chen W T. Critical appraisal of the use of matrix metalloproteinase inhibitors in cancer treatment [ J ]. Oneogene, 2000, 19(56) :6642 -50.

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临床泌尿外科杂志
2007年 第9期

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