尿白蛋白肌酐比和高敏C反应蛋白与血管病变程度的相关性研究

The correlation between urinary albumin-creatinine ratio,high-sensitivity C-reactive protein and vascular lesions

目的研究尿白蛋白肌酐比(urinary albumin creatinine ratio,UACR)和血清高敏C反应蛋白(high-sensieivi-ty C-reactive protein,hs-CRP)与血管病变程度的相关性。方法将125例不同血管病变的2型糖尿病患者分为无血管病变组(24例)、大血管病变组(57例)、微血管病变组(11例)和联合病变组(33例),分别检测UACR和血清hs-CRP,并进行组间比较。结果联合病变组UACR和血清hs-CRP显著高于其他3组(P<0.05),UACR受试者工作曲线下面积0.860大于hs-CRP曲线下面积0.679,UACR与糖化血红蛋白正相关(r=0.345,P=0.043)。结论UACR和hs-CRP都与严重血管病变相关,UACR相关性更大。

Objective To study the correlation between urinary albumin-creatinine ratio （UACR）, high-sensitivity C-reactive protein（hs-CRP） and vascular lesions. Methods 125 type-2 diabetic patients were divided into four groups according to their vascular lesions. Their UACR and serum hs-CRP were measured and compared between different groups. Results The combined lesion group had higher serum hs-CRP and UACR than other groups（ P〈0.05）. The area under receiver operating characteristic（RoC） curve of UACR was larger than area under hs-CRP curve（0. 860 vs 0. 679）. UACR was positively correlated to HbAlc （ r =0. 345, P =0. 043）. Conclusion Both UACR and hs-CRP ar.e correlated to severe vascular lesions. The UACR is more highly correlated with vascular lesion than hs-CRP does.