脑多巴胺转运体单光子发射型计算机断层显像在诊断帕金森病中的应用

The application of brain dopamine transporter ^(99)Tc^m-TRODAT-1 SPECT imaging in diagnosis of PD

目的探讨脑多巴胺转运体显像剂99Tcm-TRODAT-1在基底神经节的分布特点,以及单光子发射型计算机断层显像(SPECT)对诊断帕金森病(PD)的价值。方法将35例PD患者(PD组)和16例健康体检者(对照组)进行99Tcm-TRODAT-1 SPECT脑显像检查。以半定量方法分析,应用计算机感兴趣区(ROI)技术计算双侧横断位、矢状位纹状体(ST)/小脑(CB)放射性摄取率之比。结果对照组横断位左右侧和矢状位左、右侧ST/CB分别为(1.55±0.15)、(1.58±0.14)和(1.62±0.17)、(1.69±0.16)。PD组ST/CB比对照组明显减低,差异有显著性意义(P<0.01)。结论99Tcm-TRODAT-1在SPECT中显像是诊断PD的有效方法。

Objective To investigate the characteristics of distribution of ^99Tc^m-TRODAT-1 in the basal ganglia and evaluate the value of SPECT imaging in diagnosis of Parkinson＇s disease （PD）. Methods ^99Tc^m-TRODAT-1 SPECT imaging was used in 35 PD patients and sixteen age-matched healthy volunteers. The regions of interest were drawn manually on cerebellum （CB） ,three transverse,and sagittal plane slice-views of striatums（ST）. The uptake ratios of ST/CB were calculated using semiquantitative analysis. Results The ST/CB ratios of left and right transverse planes and sagittal planes in healthy volunteers were 1.55±0.15,1.58±0.14,1.62±0.17 and 1.69±0. 16 respectively. A lower specific uptake of ^99Tc^m-TRODAT-1 in striatums was displayed in 35 PD patients by visual inspection,compared with healthy volunteers. The uptake ratios ST/CB in the basal ganglia of PD were significantly lower than those of healthy volunteers （ P 〈0.01 ）. Conclusion ^99Tc^m-TRODAT-1 SPECT imaging is an effective method for diagnosis of PD.