抗磷脂综合征及其肾损害

Antiphospholipid syndrome and renal damage

抗磷脂综合征(APS)是一种以反复动脉或静脉血栓、流产或死胎、同时伴有抗心磷脂抗体或狼疮抗凝物试验持续阳性的疾病。APS发病机制与多种自身抗体如抗心磷脂抗体、β2糖蛋白Ⅰ抗体、抗凝血酶原抗体、抗血小板抗体等有关。APS分为原发性与继发性,两者的临床特点相似。继发性中系统性红斑狼疮最为常见。APS的肾损害包括肾血管损害、动静脉栓塞、高血压及APS肾病等。

Antiphospholipid syndrome （APS） is a disorder characterized by recurrent venous or arterial thrombosis, abortion or still-birth, and with persistently elevated levels of anticardiolipin antibody or evidence of a circulating lupus anticoagulant. The pathogenesis of APS may associate with multiple autoimmune antibodies including antiphospholipids antiody, antibeta-2 glycoprotein I antibody, antiprothrombin antibody, antiplatelet antibody, and so on. APS can be classified into primary and secondary types with similar clinical features. Systemic lupus erythematosus is common seen in the secondary type of APS. The manifestations of renal damage associated with APS include renal vascular injury, venous or arterial thrombosis, hypertension and APS nephropathy.