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沙眼衣原体耐药的分子机理研究新进展

Advances of the study on molecular basis of resistance of Chlamydia trachomatis (a review)
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摘要 近年来,耐药沙眼衣原体菌株不断增多,许多能杀灭衣原体的传统抗生素,在临床治疗中证实无效。另有研究显示,沙眼衣原体经适当的抗生素治疗会复发,会呈现衣原体持续感染状态。因此研究沙眼衣原体耐药分子机理具有重要意义。 This paper states raries drugs can induced resistance by Chlamydia trachomatis.
作者 吴亚安 郑和平
机构地区 广东医学院附属医院皮肤科 广东省皮肤性病防治中心
出处 《皮肤病与性病》 2007年第3期22-24,共3页 Dermatology and Venereology
关键词 沙眼衣原体 耐药 分子机理 chlanydia trachonatis resistance molecular basis.
分类号 R966 [医药卫生—药理学] R374.3 [医药卫生—病原生物学]
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参考文献21

  • 1Dreses-Werringloer U,Padubrin I,Kohler L,et al.Detection of nucleotide variability in rpoB in both rifampin-sensitive and rifampin-resistant strains Of Chlamydia trachomatis[J].Antimicrob Agents Chemother,2003,47:2316-2318.
  • 2Kutlin A,Kohlhoff S,Roblin P,et al.Emergence of Resistance to Rifar pin and Rifalazil in Chlamydophila pneumoniae and Chlamydia traehomatis[J].Antimicrob Agents Chemother,2005,49:903 -907.
  • 3Morrisey C,Salman I H,Bgkker S D,et al.Serial passage of chlamydia spp in subinhibitory fluoroquinolone concentrations[J].J Antimicrob Chemother,2002,49:757-761.
  • 4Martinez-Martinez L A,Pascual I,Garcia J,et al.Interaction of plasmid and host quinolone resistance[J].J Anfimicrob Chemother,2003,51:1037-1039.
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  • 6Connell S R,Tracz D M,Nierhaus K H,et al.Ribosomal protection proteins and their mechanism of tetracycline resistance[J].Antimicrob Agents Chemother,2003,47:3675-3681.
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  • 8Lenart J,ersen AA,Rockey DD.Growth and development of tetracycline-resistant Chlamydia suis[J].Anlimicrob Agents C hemothcr,2001,45:2198-2203.
  • 9Dugan J,Rockcy DD,Joncs L,et al.Tetracycline resistance in Chlamydia suis mediated by genomic islands inserted into the chlamydial inv-like gene.Antimicrob[J].Agents Chemother,2004,48:3989-3995.
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皮肤病与性病
2007年 第3期

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