乳腺癌钙化灶与ER、PR及c-erbB-2表达的关系

The Correlation Between Calcifications of Breast Cancer and the Expression of ER,PR and c-erbB-2

目的探讨乳腺癌钙化灶的特征与乳腺癌组织雌激素受体(ER)、孕激素受体(PR)及癌基因(c-erbB-2)表达的关系。资料与方法观察分析56例乳腺癌钼靶片中微小钙化灶的特征并采用免疫组织化学的方法检测乳腺癌组织中ER、PR及c-erbB-2的表达情况。结果钙化灶呈线样或段样分布的乳腺癌PR阳性率明显低于非线样或段样分布者,两者PR的表达差异有统计学意义(χ2=13.176,P<0.05),而钙化灶的形态、钙化区范围、钙化灶数目、钙化灶的密集度、钙化灶是否合并肿块与ER、PR及c-erbB-2的表达,钙化灶是否呈线样或段样分布与ER及c-erbB-2的表达差异均无统计学意义。结论钙化灶的分布特征与PR表达之间存在一定的相关性,从乳腺癌钼靶片上可粗略预测乳腺癌组织PR的表达情况,从而为临床内分泌治疗、判断疾病的预后等提供依据。

Objective To discuss the correlation between the expression of ER, PR and c-erbB-2 and calcifications of breast cancer. Materials and Methods 56 patients of breast cancer with microcalcifications found by mammography were analyzed. The expression of ER, PR and c-erbB-2 were detected with immunohistochemical technique in breast cancer. Results Significant difference in PR positive rate existed between calcifications with linear or segmental distribution pattern and calcifications without linear or segmental distribution pattern （ χ^2 = 13. 176, P 〈 0.05 ）. Conclusion The expression of PR could be predicted by the linear or triangular distribution pattern of the microcalcifications or not, which provide information for therapy and prognosis.