老年人血清不对称二甲基精氨酸与同型半胱氨酸及动脉硬化其他危险因素的相关性分析

The relationship of serum asymmetric dimethylarginine to homocysteine and traditional risk factors of atherosclerosis in elderly

目的探讨老年人血清不对称二甲基精氨酸(ADMA)的变化及其影响因素。方法离退休老干部141例为观察组,健康者31例为对照组。测定其血压、血糖、血脂和ADMA、同型半胱氨酸(Hcy)等。将ADMA与Hcy及动脉硬化的其他危险因素进行多因素相关分析。结果观察组血清ADMA和Hcy分别为(0.97±0.55)μmol/L和(28.25±10.82)μmol/L,分别高于对照组的(0.57±0.23)μmol/L和(16.66±3.75)μmol/L(P<0.01)。观察组年龄、吸烟年支、血压、肌酐、肌酐清除率、血糖、甘油三酯、总胆固醇、LDL-胆固醇和LDL/HDL比值与对照组比较均有显著性差异。经多元回归分析,观察组ADMA与年龄、吸烟年支、收缩压、肌酐、肌酐清除率、血糖和LDL/HDL比值存在显著性相关,与Hcy之间不存在相关。结论老年人血清ADMA增高与高龄、吸烟、肾功能减退、血糖增高及LDL/HDL的比值异常有关,而与叶酸降低和Hcy增高不存在相关关系。

Objective To observe the relationship of serum asymmetric dimethylarginine to homocysteine and traditional risk factors of atherosclerosis in elderly. Methods The serum levels of ADMA, Hcy, total cholesterol, triglycerides,glucose, folic acid, VB12 and creatinine were measured in 141 elderly who were defined as observed group and 31 subjects of healthy as control group. Results The serum levels of ADMA and Hcy of observed group were significantly higher than those of control group, they were （0. 97±0.55）μmol/L and （28.25±10.82）μmol/L vs （0. 57±0. 23）μmol/L and （16.66±3.75）μmol/L respectively（P〈0.01）. The relation between ADMA level and age, smoking, systolic pressure, glucose, LDL/HDL, creatinine and creatinine clearance was analysed by multiple regression. Conclusion Compared to the controls the elderly of observed group has higher serum level of ADMA and Hcy, the higher level of ADMA is associated with aging, smoking habit, decreased kidney function, higher glucose and ratio of LDL/HDL. There is no relationship between ADMA and Hcy.