摘要
目的:评价平阳霉素(PYM)单独使用或联合鱼肝油酸钠(SM)和地塞米松(DXM)瘤内注射治疗口腔颌面部静脉畸形的疗效和安全性。方法:选择100例口腔颌面部静脉畸形患者,随机分为两组。PYM组50例瘤腔内单独注射PYM;联合用药组50例,用DXM 5 mg/ml加2%利多卡因4ml瘤内注射,尔后再据年龄、瘤体大小,局部情况注射0.5~2.0mlSM。均5~7d注射1次,3~5次为一个疗程。分析其疗效和安全性。结果:治疗后经6~48个月随访。PYM组有效率84.0%,联合用药组有效率96.0%。明显高于PYM组(P<0.05)。PYM组有5例(10.0%)出现发热,联合用药组无发热病例(P<0.05)。结论:PYM、DXM、SM联合注射治疗口腔颌面部静脉畸形,具有疗程短、不良反应小等优点,是一种安全、可靠、简便的治疗方法,其疗效优于PYM单独瘤内注射治疗。
Objective:To evaluate the effect and safty Pingyangmycin (PYM) injected single or PYM, Dexamethasonum (DXM) and Sodium Morrhuate (SM) combined injetction to treat venous malformation in the oral and maxillofacial regions. Method-100 patients with venous malformation were divided into two groups at random with 45 in each .Group of PYM (single)were given intralesional injection of PYM 1-5 ml (8 mg PYM was dissolved in 5ml of 2% Lidocain) : Group of Combine were treated by combined intralesional injection of PYM, DXM and SM.Treatment procedure: ①Preparation: 8 mg PYM was dissolved in 5 mg / ml DXM and in 4ml of 2% Lidocain,which were ready for use:②1-5 ml (PYM 1.6 -8.0 mg) of mixed solution was first injected to the intralesion, then followed by an injection of 0.5 -2ml SM according to Patient's age, size of the tumor and local appearance.Each group of the injection was administered once erery 5 to 7 days for 3 to 5 weeks. The effect and safety was studied by clinical examination and follow-up. Result: The cases were followed up for 6 -48 months.The effective rate of intralesion injection of PYM is 84.0%, and the effectivity of conbined injection is 96.0%.There was statistically difference on the effect between the group of PYM and the group of combine. (P〈 0.05) 5patients (10.0%) got fever in PYM group .No cases was fever in combine group. (P〈0.05) Conclusion:This combined injection may be a safe, simple, short course, lower side reaction and effective therapy for venous malformation of the oral and maxillofacial regions.It was better than PYM single injection in the effectivity and safty.
出处
《临床口腔医学杂志》
2007年第9期552-553,共2页
Journal of Clinical Stomatology
关键词
静脉畸形
平阳霉素
鱼肝油酸钠
地塞米松:口腔颌面部
venous malformation
pingyangmycin
sodium morrhuate
dexamethasonum
oral and maxillofacial regions