急性缺血性脑水肿微血管形态功能改变及高压氧治疗的效用

Changes of figure,function and curing effect of hyperbaric oxygen in acute ischemic cerebral edema

目的探讨缺血性脑水肿脑神经细胞、微血管结构与功能的改变及高压氧治疗的效用。方法沙土鼠60只随机分成3组。阻断动物双侧颈动脉30 min造成急性缺血性脑损伤,通过微循环显微镜和电镜观察动物缺血性脑水肿及高压氧治疗后微血管结构功能改变。结果高压氧暴露后,缺血性脑损伤动物大脑神经细胞肿胀改善,大多数神经细胞形态正常,微血管周围仅有少量渗出,内皮细胞损伤明显减轻,脑组织水肿开始吸收。缺血性脑损伤动物经0.25 MPa高压氧暴露后,细动脉血流速度平均净增加0.88 mm/s,细静脉净增加0.34 mm/s。结论高压氧暴露可通过减轻细胞损伤和改善微血管功能,达到对缺血性脑水肿的治疗作用。

Objective To approach changes in the figue and function of cerebral nerve cell during ischemic cerebral edema and the effect of hyperbaric oxygen （ HBO ） treatment. Methods Sixty gerbils were divided into three groups. Both carotid artery were blocked for 30 min to form acute cerebral ischemic injury. The change characteristics were observed with microcircnlation microscope and electron microscope in structure and function of cerebral microvessels during ischemic cerebral edema and HBO exposure. Results After HBO exposure,cerebral nerve cell swelling was improved in acute cerebral ischemic injured animal. Majority nerve cell was normal. There was only small quantity exudation in environment of microvessels. And injury of endothelial cell obviously reduced. Cerebral tissue edema began to be absorbed. After HBO exposure at 0.25 MPa blood flow rate in arteriole increased 0. 88 mm/s averagely, and veinule increased 0. 34 mm/s. Conclusions HBO has therapeutic effect on ischemic cerebral edema by reducing cell injury and improving microvessel function.